Chrysin promotes angiogenesis in rat hindlimb ischemia: Impact on PI3K/Akt/mTOR signaling pathway and autophagy
Sign Up to like & getrecommendations! Published in 2022 at "Drug Development Research"
DOI: 10.1002/ddr.21954
Abstract: Limb ischemia occurs due to obstruction of blood perfusion to lower limbs, a manifestation that is associated with peripheral artery disease (PAD). Angiogenesis is important for adequate oxygen delivery. The present study investigated a potential… read more here.
Keywords: akt mtor; mtor; pi3k akt; chrysin ... See more keywords
Combined effect of chrysin and apigenin on inhibiting the development and progression of colorectal cancer by suppressing the activity of P38‐MAPK/AKT pathway
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DOI: 10.1002/iub.2456
Abstract: Either apigenin or chrysin alone has been found to exert anti‐inflammatory and tumor suppressive effect. However, the combined effect of apigenin and chrysin on colorectal cancer (CRC) has not been fully clarified. We attempted to… read more here.
Keywords: chrysin; apigenin chrysin; effect; chrysin apigenin ... See more keywords
Potentiating apoptosis and modulation of p53, Bcl2, and Bax by a novel chrysin ruthenium complex for effective chemotherapeutic efficacy against breast cancer
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DOI: 10.1002/jcp.27287
Abstract: Breast cancer is the most frequent cause of cancer in women. In the current study, transition metal ruthenium was complexed with flavonoid chrysin to evaluate the chemotherapeutic potential of this compound in Michigan Cancer Foundation‐7… read more here.
Keywords: ruthenium; chrysin; breast cancer; cancer ... See more keywords
Chrysin boosts KLF2 expression through suppression of endothelial cell-derived exosomal microRNA-92a in the model of atheroprotection
Sign Up to like & getrecommendations! Published in 2021 at "European Journal of Nutrition"
DOI: 10.1007/s00394-021-02593-1
Abstract: Atherosclerosis and its related clinical complications are the leading cause of death. MicroRNA (miR)-92a in the inflammatory endothelial dysfunction leads to atherosclerosis. Krüppel-like factor 2 (KLF2) is required for vascular integrity and endothelial function maintenance.… read more here.
Keywords: chrysin; endothelial cell; mir 92a; klf2 expression ... See more keywords
Chrysin attenuates interstitial fibrosis and improves cardiac function in a rat model of acute myocardial infarction
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Molecular Histology"
DOI: 10.1007/s10735-018-9793-0
Abstract: Interstitial fibrosis after acute myocardial infarction (MI) leads to cardiac structural remodeling and dysfunction. The peroxisome proliferator-activated receptor-gamma (PPAR-γ) agonist chrysin has been shown to protect injured myocardium through suppression of oxidative stress and inflammation.… read more here.
Keywords: interstitial fibrosis; fibrosis; myocardial infarction; chrysin ... See more keywords
Chrysin/β-cyclodextrin supramolecular system: a quantum mechanical investigation
Sign Up to like & getrecommendations! Published in 2018 at "Journal of the Iranian Chemical Society"
DOI: 10.1007/s13738-018-1429-5
Abstract: Chrysin is a bioflavonoid which possesses a wide range of important biological activities. In present study, we used a quantum mechanical approach to shed light on the antioxidant ability and antioxidant mechanism of chrysin to… read more here.
Keywords: supramolecular system; chrysin complex; cyclodextrin supramolecular; chrysin ... See more keywords
Chrysin reverses the depressive‐like behavior induced by hypothyroidism in female mice by regulating hippocampal serotonin and dopamine
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Pharmacology"
DOI: 10.1016/j.ejphar.2018.01.017
Abstract: Abstract Hypothyroidism is often associated with psychiatric disorders such as depression. In this study, we evaluated the effect of chrysin on depressive‐like behavior and monoamine levels in hypothyroid female mice. Hypothyroidism was induced by continuous… read more here.
Keywords: hypothyroidism; chrysin; like behavior; depressive like ... See more keywords
Transcriptome analysis of two structurally related flavonoids; Apigenin and Chrysin revealed hypocholesterolemic and ketogenic effects in mouse embryonic fibroblasts.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2020.173804
Abstract: There is no known single therapeutic drug for treating hypercholesterolemia that comes with negligible systemic side effects. In the current study, using next generation RNA sequencing approach in mouse embryonic fibroblasts we discovered that two… read more here.
Keywords: embryonic fibroblasts; two structurally; chrysin; apigenin chrysin ... See more keywords
Microwave-assisted β-cyclodextrin/chrysin inclusion complexation: An economical and green strategy for enhanced hemocompatibility and chemosensitivity in vitro
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DOI: 10.1016/j.molliq.2020.113257
Abstract: Abstract Chrysin (5, 7-dihydroxyflavone) (CHR), a wonder flavonoid that nature has bestowed upon us, is endowed with a broad spectrum of pharmacological properties. Nonetheless, the practical uses of CHR are greatly impeded owing to its… read more here.
Keywords: inclusion; chemosensitivity; chrysin; microwave assisted ... See more keywords
Palladium(II) complexes bearing di-(2-picolyl)amine functionalized chrysin fragments. An experimental and theoretical study
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DOI: 10.1016/j.molstruc.2017.05.076
Abstract: Abstract A new series of chrysin derivatives containing the di-(2-picolyl)amine (2a–d) moiety have been designed, synthesized, and treated with PdCl2·2CH3CN allowing the preparation of new cationic Palladium(II) complexes (3a–d). Solution-phase studies by 1H NMR spectroscopy… read more here.
Keywords: palladium complexes; chrysin; picolyl amine; experimental theoretical ... See more keywords
Chrysin protects against behavioral, cognitive and neurochemical alterations in a 6-hydroxydopamine model of Parkinson's disease
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DOI: 10.1016/j.neulet.2019.05.036
Abstract: Parkinson's disease (PD) is an age-related neurodegenerative disorder that severely affects quality of life of patients and their families. The flavonoid chrysin (5,7-dihydroxylflavone) is a naturally occurring flavone with several pharmacological activities, including anti-inflammatory and… read more here.
Keywords: chrysin; behavioral cognitive; model; parkinson disease ... See more keywords