Chrysophanol attenuated isoproterenol‐induced cardiac hypertrophy by inhibiting Janus kinase 2/signal transducer and activator of transcription 3 signaling pathway
Sign Up to like & getrecommendations! Published in 2019 at "Cell Biology International"
DOI: 10.1002/cbin.11146
Abstract: Cardiac hypertrophy is a common pathological change found in various cardiovascular diseases. Although it has long been recognized as an important risk factor responsible for heart failure, there is still a lack of effective treatments… read more here.
Keywords: cardiac hypertrophy; transcription; induced cardiac; hypertrophy ... See more keywords
The potential antitumor effect of chrysophanol in relation to cervical cancer cells
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DOI: 10.1002/jcb.29891
Abstract: Chrysophanol is an anthraquinone with proven antitumor activity against several tumor cell lines. However, its effect on cervical cancer cells is still unknown. Therefore, HeLa cells were exposed to various concentrations of chrysophanol and then… read more here.
Keywords: cervical cancer; effect; effect chrysophanol; chrysophanol ... See more keywords
Molecular mechanisms of anti‐inflammatory effect of chrysophanol, an active component of AST2017‐01 on atopic dermatitis in vitro models
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DOI: 10.1016/j.intimp.2017.11.019
Abstract: ABSTRACT AST2017‐01 mainly consists of Rumex crispus and ‐Cordyceps militaris and has been widely consumed as an herbal medicine or functional food in Korea. Here we investigated the influences of AST2017‐01 and its active component,… read more here.
Keywords: ast2017 chrysophanol; medicine; active component; chrysophanol ... See more keywords
Chrysophanol inhibits the osteoglycin/mTOR and activats NF2 signaling pathways to reduce viability and proliferation of malignant meningioma cells
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DOI: 10.1080/21655979.2021.1885864
Abstract: ABSTRACT Chrysophanol shows promising antitumor activity, but how it may work against malignant meningioma is poorly understood. In addition, osteoglycin (OGN) may help mediate the antitumor effects of chrysophanol; thus, this study investigated the potential… read more here.
Keywords: malignant meningioma; nf2 signaling; viability; mtor ... See more keywords
Chrysophanol prevents IL-1β-Induced inflammation and ECM degradation in Osteoarthritis via the Sirt6/NF-κB and Nrf2/NF-κB axis.
Sign Up to like & getrecommendations! Published in 2022 at "Biochemical pharmacology"
DOI: 10.2139/ssrn.4217537
Abstract: Osteoarthritis (OA) is a common joint illness that negatively impacts people's lives. The main active ingredient of cassia seed or rhubarb is chrysophanol. It has various pharmacological effects including anticancer, anti-diabetes and blood lipid regulation.… read more here.
Keywords: nrf2 axis; osteoarthritis; sirt6 nrf2; chrysophanol ... See more keywords
Chrysophanol: A Natural Anthraquinone with Multifaceted Biotherapeutic Potential
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DOI: 10.3390/biom9020068
Abstract: Chrysophanol is a unique anthraquinone having broad-spectrum therapeutic potential along with ecological importance. It is the first polyketide that has been reported to be biosynthesized in an organism-specific manner. The traditional Chinese and Korean medicinal… read more here.
Keywords: natural anthraquinone; anthraquinone multifaceted; anthraquinone; potential ... See more keywords
Nephroprotective Role of Chrysophanol in Hypoxia/Reoxygenation-Induced Renal Cell Damage via Apoptosis, ER Stress, and Ferroptosis
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DOI: 10.3390/biomedicines9091283
Abstract: Acute kidney injury (AKI) is caused by hypoxia-reoxygenation (H/R), which is a kidney injury produced by a variety of causes, resulting in the remaining portion of the kidney function being unable to maintain the balance… read more here.
Keywords: medicine; hypoxia reoxygenation; apoptosis; stress ... See more keywords
Anti-Apoptotic Effect of Chrysophanol Isolated from Cassia tora Seed Extract on Blue-Light-Induced A2E-Loaded Human Retinal Pigment Epithelial Cells
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DOI: 10.3390/ijms24076676
Abstract: The seeds of Cassia tora (C. tora) species mainly contain anthraquinone, anthraquinone glycoside, and naphthalene derivatives. We investigated the anti-apoptotic effects of C. tora seed extract and its isolated compounds on blue-light-induced lipofuscin (A2E)-loaded human… read more here.
Keywords: loaded human; blue light; a2e loaded; chrysophanol ... See more keywords
Chrysophanol Attenuates Manifestations of Immune Bowel Diseases by Regulation of Colorectal Cells and T Cells Activation In Vivo
Sign Up to like & getrecommendations! Published in 2021 at "Molecules"
DOI: 10.3390/molecules26061682
Abstract: Inflammatory bowel disease (IBD) is an immune disorder that develops due to chronic inflammation in several cells. It is known that colorectal and T cells are mainly involved in the pathogenesis of IBD. Chrysophanol is… read more here.
Keywords: bowel; chrysophanol attenuates; ibd; chrysophanol ... See more keywords