Association between dengue severity and plasma levels of dengue-specific IgE and chymase
Sign Up to like & getrecommendations! Published in 2018 at "Archives of Virology"
DOI: 10.1007/s00705-018-3849-z
Abstract: There is no definitive predictor of dengue severity, and this has led to a very large number of unnecessary hospitalizations worldwide. Although mast cell mediators are believed to a play role in dengue severity, the… read more here.
Keywords: chymase; dengue severity; specific ige; dengue specific ... See more keywords
Mast cell peptidases (carboxypeptidase A and chymase)-mediated hydrolysis of human angiotensin-(1-12) substrate.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2019.08.098
Abstract: Angiotensin processing peptidases (carboxypeptidase A (CPA) and chymase) are stored in cardiac mast cell (MC) secretory granules in large quantity and are co-released into the extracellular environment after activation/degranulation. In the human heart, chymase is… read more here.
Keywords: chymase; rhchymase; hang; ang ... See more keywords
ASB17061, a novel chymase inhibitor, prevented the development of angiotensin II-induced abdominal aortic aneurysm in apolipoprotein E-deficient mice.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2019.05.032
Abstract: Our aim was to examine the effects of ASB17061, an orally active novel chymase inhibitor, on angiotensin II-induced abdominal aortic aneurysm (AAA) in apolipoprotein E-deficient mice. Oral administration of ASB17061 (10 mg/kg) significantly suppressed angiotensin II-induced… read more here.
Keywords: chymase; novel chymase; angiotensin induced; induced abdominal ... See more keywords
Elevated salivary activity of mast cell chymase of periodontitis patients, and a new bradykinin generation cascade, mediating the cross-talks between mast cell and gingival fibroblast.
Sign Up to like & getrecommendations! Published in 2021 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2021.108269
Abstract: Activated-mast cells (MCs) within gingival-tissue of chronic-periodontitis (CP) patients, release various inflammatory-factors. Bradykinin is a nine-amino-acid peptide and pro-inflammatory mediator, produced through factor-XII-cascade or tryptase-cascade. The ability of MC-chymase in bradykinin generation has not been… read more here.
Keywords: bradykinin generation; cell; chymase; mast cell ... See more keywords
Opening the Door to a New Treatment Paradigm: The Re-emergence of Chymase Inhibitors.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.5c00413
Abstract: Chymase is a serine protease that has been studied as a drug target in inflammatory diseases, so far with limited success. Fulacimstat is a novel drug candidate inhibiting chymase that has been investigated in clinical… read more here.
Keywords: chymase inhibitors; door new; new treatment; chymase ... See more keywords
Role of chymase in blood pressure control, plasma and tissue angiotensin II, renal Haemodynamics, and excretion in spontaneously hypertensive rats
Sign Up to like & getrecommendations! Published in 2021 at "Clinical and Experimental Hypertension"
DOI: 10.1080/10641963.2021.1890762
Abstract: ABSTRACT Background: Chymase generates angiotensin II (ANG II) independently of angiotensin-converting enzyme in tissues and it contributes to vascular remodeling and development of hypertension, however the exact mechanism of its action is unclear. Methods: Hence,… read more here.
Keywords: chymase; spontaneously hypertensive; hypertensive rats; blood pressure ... See more keywords
Aedes albopictus salivary proteins adenosine deaminase and 34k2 interact with human mast cell specific proteases tryptase and chymase
Sign Up to like & getrecommendations! Published in 2022 at "Bioengineered"
DOI: 10.1080/21655979.2022.2081652
Abstract: ABSTRACT When mosquitoes probe to feed blood, they inoculate a mixture of salivary molecules into vertebrate hosts’ skin causing acute inflammatory reactions where mast cell-derived mediators are involved. Mosquito saliva contains many proteins with largely… read more here.
Keywords: chymase; mast cell; tryptase chymase;
Mouse chymase mast cell protease-4 facilitates blood feeding of Aedes aegypti (Diptera: Culicidae) mosquitoes.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of medical entomology"
DOI: 10.1093/jme/tjaf137
Abstract: Aedes aegypti (Linnaeus) are rapidly spreading across the globe. Evidence suggests that a Type I hypersensitivity reaction, characterized by IgE-mediated mast cell degranulation, may enhance the blood-feeding behavior of Ae. aegypti. Chymases, the mast cell-specific… read more here.
Keywords: blood; blood feeding; chymase; mast cell ... See more keywords
Estimation of serum levels of mast cells-related chymase, histamine and diamine oxidase in oral submucous fibrosis- a preliminary report
Sign Up to like & getrecommendations! Published in 2025 at "BMC Oral Health"
DOI: 10.1186/s12903-025-05772-2
Abstract: Mast cell infiltration in oral submucous fibrosis (OSMF) has been drawn in to play a definitive role in initiation, progression, and symptom like burning sensation. Degranulation products of mast cells like tryptase and chymase have… read more here.
Keywords: serum; chymase; mast cells; diamine oxidase ... See more keywords
Impact of early pericardial fluid chymase activation after cardiac surgery
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Cardiovascular Medicine"
DOI: 10.3389/fcvm.2023.1132786
Abstract: Introduction Chymase is a highly destructive serine protease rapidly neutralized in the circulation by protease inhibitors. Here we test whether pericardial fluid (PCF) chymase activation and other inflammatory biomarkers determine intensive care unit length of… read more here.
Keywords: chymase activation; pcf; surgery; cardiac surgery ... See more keywords
Pathophysiological Role of Chymase-Activated Matrix Metalloproteinase-9
Sign Up to like & getrecommendations! Published in 2022 at "Biomedicines"
DOI: 10.3390/biomedicines10102499
Abstract: Chymase present in mast cells can directly form matrix metalloproteinase (MMP)-9 from proMMP-9. Chymase-activated MMP-9 has been reportedly closely related to the pathogenesis of various diseases, and inflammation-related diseases in particular. Upregulated chymase and MMP-9… read more here.
Keywords: chymase activated; role chymase; chymase; mmp ... See more keywords