Mast cell chymase in synovial fluid of collagen-induced-arthritis rats regulates gelatinase release and promotes synovial fibroblasts proliferation via FAK/p21 signaling pathway.
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DOI: 10.1016/j.bbrc.2019.04.121
Abstract: Mast cells (MCs) were accumulated in synovial tissue of rheumatoid arthritis (RA) patients. MC activation releases numerous mediators including MC-chymase. Synovial fibroblast shows a dramatic hyperplasia in RA articular cavity, but the effects of MC-chymase… read more here.
Keywords: synovial fibroblasts; chymase synovial; synovial fibroblast; arthritis ... See more keywords