Mercury(II) binds to both of chymotrypsin's histidines, causing inhibition followed by irreversible denaturation/aggregation
Sign Up to like & getrecommendations! Published in 2017 at "Protein Science"
DOI: 10.1002/pro.3082
Abstract: The toxicity of mercury is often attributed to its tight binding to cysteine thiolate anions in vital enzymes. To test our hypothesis that Hg(II) binding to histidine could be a significant factor in mercury's toxic… read more here.
Keywords: aggregation; precipitation; chymotrypsin; denaturation aggregation ... See more keywords
First insights into insecticidal activity against Aedes aegypti and partial biochemical characterization of a novel low molecular mass chymotrypsin-trypsin inhibitor purified from Lonchocarpus sericeus seeds.
Sign Up to like & getrecommendations! Published in 2018 at "Pest management science"
DOI: 10.1002/ps.4812
Abstract: BACKGROUND Arboviroses such as dengue, Zika and chikungunya represent a serious public health issue as a consequence of the absence of approved vaccines or specific antiviral drugs against the arboviruses that cause them. One way… read more here.
Keywords: aedes aegypti; inhibitor; mass; chymotrypsin ... See more keywords
Design and optimization of an alternative chymotrypsin purification method by adsorption onto non-soluble alginate–carrageenan bed
Sign Up to like & getrecommendations! Published in 2020 at "Polymer Bulletin"
DOI: 10.1007/s00289-020-03151-1
Abstract: In the present work, we have developed a new protocol for the purification of chymotrypsin using adsorption onto non-soluble alginate–carrageenan bed. In the first instance, an experimental statistical design was used to screen which parameters… read more here.
Keywords: adsorption; adsorption onto; chymotrypsin; non soluble ... See more keywords
Chymotrypsin with sialendoscopy-assisted surgery for the treatment of chronic obstructive parotitis.
Sign Up to like & getrecommendations! Published in 2017 at "International journal of oral and maxillofacial surgery"
DOI: 10.1016/j.ijom.2017.02.1267
Abstract: Chronic obstructive parotitis (COP) is a common disease of the parotid gland. A total of 104 patients with COP were identified and randomized into a treatment group (52 cases) and a control group (52 cases).… read more here.
Keywords: chronic obstructive; surgery; treatment; obstructive parotitis ... See more keywords
Structural characterization of α‑chymotrypsin after binding to curcumin: Spectroscopic and computational analysis of their binding mechanism
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Molecular Liquids"
DOI: 10.1016/j.molliq.2019.111111
Abstract: Abstract Food has a major role in sickness, traditional medicine, and curing. Curcuma longa L. is one of these medicinal plants. Curcuma longa L., a member of the ginger family, grows in tropical regions of… read more here.
Keywords: medicine; curcumin; structural characterization; spectroscopy ... See more keywords
Protein Separation Coacervation with Carboxymethyl Cellulose of Different Substitution Degree: Noninteracting Behavior of Bowman-Birk Chymotrypsin Inhibitor.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.8b00091
Abstract: We first observed that protein/polysaccharide interaction exhibited noninteracting behavior which makes Bowman-Birk chymotrypsin inhibitor (BBI) always free of complexation, being separated from another protein with similar isoelectric points, Kunitz trypsin inhibitor (KTI). Turbidity titrations showed… read more here.
Keywords: protein; inhibitor; chymotrypsin; bowman birk ... See more keywords
A Bowman-Birk type chymotrypsin inhibitor peptide from the amphibian, Hylarana erythraea
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DOI: 10.1038/s41598-018-24206-4
Abstract: The first amphibian skin secretion-derived Bowman-Birk type chymotrypsin inhibitor is described here from the Asian green frog, Hylarana erythraea, and was identified by use of molecular cloning and tandem mass spectrometric amino acid sequencing. It… read more here.
Keywords: chymotrypsin inhibitor; inhibitor; hylarana erythraea; chymotrypsin ... See more keywords
Loss of chymotrypsin-like protease (CTRL) alters intrapancreatic protease activation but not pancreatitis severity in mice
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DOI: 10.1038/s41598-020-68616-9
Abstract: The digestive enzyme chymotrypsin protects the pancreas against pancreatitis by reducing harmful trypsin activity. Genetic deficiency in chymotrypsin increases pancreatitis risk in humans and pancreatitis severity in mice. Pancreatic chymotrypsin is produced in multiple isoforms… read more here.
Keywords: pancreatitis; protease; ctrl; chymotrypsin ... See more keywords
Thiol–ene photoimmobilization of chymotrypsin on polysiloxane gels for enzymatic peptide synthesis
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DOI: 10.1039/c7ra13320k
Abstract: Chemical incorporation of enzymes onto polymeric materials has recently attracted intense scientific attention. Cross-linked polysiloxane gels as a typical super-hydrophobic support, are a good candidate for supporting enzymes in low-water organic medium to efficiently catalyze… read more here.
Keywords: thiol ene; chymotrypsin; peptide synthesis; polysiloxane ... See more keywords
Divergent Protein Synthesis of Bowman–Birk Protease Inhibitors, their Hydrodynamic Behavior and Co-crystallization with α-Chymotrypsin
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DOI: 10.1055/s-0036-1588840
Abstract: A divergent protein synthesis strategy was executed to effectively synthesize Bowman–Birk protease inhibitor (BBI) analogues using native chemical ligation of peptide hydrazides. Grafting selected residues from a potent trypsin inhibitor, sunflower trypsin inhibitor-1, onto the… read more here.
Keywords: protein; chymotrypsin; bowman birk; protein synthesis ... See more keywords
α-Chymotrypsin-Induced Acetalization of Aldehydes and Ketones with Alcohols
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DOI: 10.1055/s-0039-1690883
Abstract: This is the first report of a simple and general method for acetalization of aldehydes via an α-chymotrypsin-induced reaction under mild conditions. A broad range of aromatic and heteroaromatic aldehydes have been acetalized under neutral… read more here.
Keywords: induced acetalization; aldehydes ketones; acetalization aldehydes; chymotrypsin ... See more keywords