Rational Design of Chymotrypsin Inhibitor 2 by Optimizing Non-Native Interactions
Sign Up to like & getrecommendations! Published in 2020 at "Journal of chemical information and modeling"
DOI: 10.1021/acs.jcim.9b00911
Abstract: Rational design of proteins via mutagenesis is crucial for several biotechnological applications. A significant challenge of the computational strategies used to predict optimized mutations is to understand the influence of each amino acid during the… read more here.
Keywords: rational design; chymotrypsin inhibitor; non native; design ... See more keywords
A Bowman-Birk type chymotrypsin inhibitor peptide from the amphibian, Hylarana erythraea
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DOI: 10.1038/s41598-018-24206-4
Abstract: The first amphibian skin secretion-derived Bowman-Birk type chymotrypsin inhibitor is described here from the Asian green frog, Hylarana erythraea, and was identified by use of molecular cloning and tandem mass spectrometric amino acid sequencing. It… read more here.
Keywords: chymotrypsin inhibitor; inhibitor; hylarana erythraea; chymotrypsin ... See more keywords
Synergistic stabilization of a double mutant in chymotrypsin inhibitor 2 from a library screen in E. coli
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DOI: 10.1038/s42003-021-02490-7
Abstract: Most single point mutations destabilize folded proteins. Mutations that stabilize a protein typically only have a small effect and multiple mutations are often needed to substantially increase the stability. Multiple point mutations may act synergistically… read more here.
Keywords: synergistic stabilization; screen coli; stability; chymotrypsin inhibitor ... See more keywords