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   Articles with "ciap1" as a keyword



Lobaplatin induces pyroptosis through regulating cIAP1/2, Ripoptosome and ROS in nasopharyngeal carcinoma.

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recommendations! Published in 2020 at "Biochemical pharmacology"

DOI: 10.1016/j.bcp.2020.114023

Abstract: Cisplatin is the most commonly used chemotherapeutic drug for nasopharyngeal carcinoma (NPC), while its side effects are often intolerable. Lobaplatin, as an effective third-generation platinum with fewer adverse reactions and less platinum cross-resistance, has been… read more here.

Keywords: ciap1; cisplatin; lobaplatin; nasopharyngeal carcinoma ... See more keywords

Abstract 5088: Evaluating TNF-receptor associated factor 2 (TRAF2) as a targetable driver of immune resistance in LKB1 deficient non-small cell lung cancer

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recommendations! Published in 2024 at "Cancer Research"

DOI: 10.1158/1538-7445.am2024-5088

Abstract: STK11 is a serine-threonine kinase and tumor suppressor lost in about 25% of NSCLC. It potently regulates a network of downstream effector kinases in the AMPK family, thereby exerting major effects on cell signaling, metabolic… read more here.

Keywords: cancer; resistance; traf2; ciap1 ... See more keywords
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Shikonin promotes ubiquitination and degradation of cIAP1/2-mediated apoptosis and necrosis in triple negative breast cancer cells

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recommendations! Published in 2021 at "Chinese Medicine"

DOI: 10.1186/s13020-021-00426-1

Abstract: Background Shikonin (SKO) is a natural naphthoquinone derived from Chinese herbal medicine Arnebiae Radix with high development potentials due to its anti-inflammatory and anti-tumor activities. Overwhelming evidences have indicated that SKO can induce both necrosis and… read more here.

Keywords: necrosis; degradation; medicine; apoptosis ... See more keywords

Inhibition of cIAP1 in the effective suppression of chemotherapy‑resistant hepatoblastoma.

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recommendations! Published in 2022 at "Oncology reports"

DOI: 10.3892/or.2022.8290

Abstract: Cellular inhibitor of apoptosis protein‑1 (cIAP1) is a key regulator of programmed cell death and is known to be associated with chemotherapeutic resistance. The present study aimed to investigate the antitumor efficacy of birinapant, a… read more here.

Keywords: chemotherapy; cddp; inhibition; ciap1 ... See more keywords