Ca2+ functions as a molecular switch that controls the mutually exclusive complex formation of pyridoxal phosphatase with CIB1 or calmodulin
Sign Up to like & getrecommendations! Published in 2020 at "FEBS Letters"
DOI: 10.1002/1873-3468.13795
Abstract: Pyridoxal 5′‐phosphate (PLP) is an essential cofactor for neurotransmitter metabolism. Pyridoxal phosphatase (PDXP) deficiency in mice increases PLP and γ‐aminobutyric acid levels in the brain, yet how PDXP is regulated is unclear. Here, we identify… read more here.
Keywords: phosphatase; mutually exclusive; pdxp; pyridoxal phosphatase ... See more keywords
Discovery and Characterization of Peptide Inhibitors for CIB1.
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DOI: 10.1021/acschembio.0c00144
Abstract: Calcium and integrin binding protein 1 (CIB1) is an EF-hand-containing, small intracellular protein that has recently been implicated in cancer cell survival and proliferation. In particular, CIB1 depletion significantly impairs tumor growth in triple-negative breast… read more here.
Keywords: cib1; h10 pocket; inhibitors cib1; characterization peptide ... See more keywords
Binding of CIB1 to the αIIb tail of αIIbβ3 is required for FAK recruitment and activation in platelets
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DOI: 10.1371/journal.pone.0176602
Abstract: Background It is believed that activation of c-Src bound to the integrin β3 subunit initiates outside-in signaling. The involvement of αIIb in outside-in signaling is poorly understood. Objectives We have previously shown that CIB1 specifically… read more here.
Keywords: iib required; cib1 iib; outside signaling; activation ... See more keywords
Identification of calcium and integrin-binding protein 1 as a reprogrammed glucose metabolism mediator to restrict immune cell infiltration in the stromal compartment of pancreatic ductal adenocarcinoma
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2023.1158964
Abstract: An increasing body of evidence has suggested that reprogrammed metabolism plays a critical role in the progression of pancreatic ductal adenocarcinoma (PDAC) by affecting the tumor and stromal cellular components in the tumor microenvironment (TME).… read more here.
Keywords: cell; metabolism; cib1; compartment ... See more keywords