A Rare Case of CIC‐DUX4 Sarcoma in a Mediastinal Lymph Node Diagnosed by Fine Needle Aspiration Cytology
Sign Up to like & getrecommendations! Published in 2025 at "Diagnostic Cytopathology"
DOI: 10.1002/dc.70038
Abstract: CIC‐rearranged sarcomas (CDS) are rare, aggressive undifferentiated small round cell tumors recently classified as a distinct entity by the World Health Organization. These tumors are defined by CIC gene fusions, most commonly CIC::DUX4, and are… read more here.
Keywords: fine needle; needle aspiration; cic dux4; case ... See more keywords
Abstract 3721: The C1 domain of capicua has functional importance in human CIC-DUX4
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-3721
Abstract: Genomic rearrangements between the HMG-box family transcriptional repressor capicua (CIC) and multiple partner genes result in fusion oncoproteins that activate transcription to drive sarcoma growth and progression. In the case of CIC-DUX4, the most common… read more here.
Keywords: cic; functional importance; cic dux4; human cic ... See more keywords
Abstract A074 Uncovering chemoresistance mechanisms in CIC-DUX4 sarcoma using a novel xenograft model
Sign Up to like & getrecommendations! Published in 2024 at "Cancer Research"
DOI: 10.1158/1538-7445.pediatric24-a074
Abstract: Objective: Capicua-double homeobox 4 (CIC-DUX4)–rearranged sarcomas (CDS) are exceptionally rare and highly aggressive tumors that usually develop in soft tissues in children, adolescents, and adults. These sarcomas exhibit high rates of metastasis and quickly develop… read more here.
Keywords: treatment; cic dux4; chemotherapy; cell ... See more keywords
CIC-DUX4 Rearranged Sarcoma Presenting in the Skin: Case Report
Sign Up to like & getrecommendations! Published in 2024 at "Case Reports in Oncology"
DOI: 10.1159/000539501
Abstract: Abstract Introduction: Capicua transcriptional repressor (CIC)-DUX4 rearranged sarcoma is a subtype of CIC-rearranged sarcomas composed of undifferentiated Wilms’ tumor 1 (WT1)+, CD99+ round cells with recurrent CIC gene rearrangement. The diagnosis of CIC-rearranged sarcoma remains… read more here.
Keywords: cic dux4; cic; dux4 rearranged; case ... See more keywords