CIC protein instability contributes to tumorigenesis in glioblastoma
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DOI: 10.1038/s41467-018-08087-9
Abstract: Capicua (CIC) is a transcriptional repressor that counteracts activation of genes downstream of receptor tyrosine kinase (RTK)/Ras/ERK signaling. It is well-established that tumorigenesis, especially in glioblastoma (GBM), is attributed to hyperactive RTK/Ras/ERK signaling. While CIC… read more here.
Keywords: degradation; tumorigenesis; glioblastoma; cic protein ... See more keywords