Efficacy of antifungal agents against fungal spores: An in vitro study using microplate laser nephelometry and an artificially infected 3D skin model
Sign Up to like & getrecommendations! Published in 2022 at "MicrobiologyOpen"
DOI: 10.1002/mbo3.1257
Abstract: Dermal fungal infections seem to have increased over recent years. There is further a shift from anthropophilic dermatophytes to a growing prevalence of zoophilic species and the emergence of resistant strains. New antifungals are needed… read more here.
Keywords: using microplate; skin; sertaconazole nitrate; microplate laser ... See more keywords
High-throughput screening identifies compounds that protect RPE cells from physiological stressors present in AMD.
Sign Up to like & getrecommendations! Published in 2019 at "Experimental eye research"
DOI: 10.1016/j.exer.2019.04.009
Abstract: Dysfunction and eventual loss of retinal pigment epithelial (RPE) cells is a hallmark of atrophic age-related macular degeneration (AMD), and linked to oxidative and nitrosative damage. Herein, we use a high-throughput screen (HTS) to identify… read more here.
Keywords: ciclopirox olamine; protect rpe; rpe cells; stress ... See more keywords
Reactive oxygen and nitrogen species are crucial for the antifungal activity of amorolfine and ciclopirox olamine against the dermatophyte Trichophyton interdigitale.
Sign Up to like & getrecommendations! Published in 2022 at "Medical mycology"
DOI: 10.1093/mmy/myac058
Abstract: Onychomycosis is a nail infection caused by Trichophyton interdigitale and other fungi, which can be treated with topical amorolfine (AMR) and ciclopirox olamine (CPX). Although these drugs are widely used, little is known about the… read more here.
Keywords: amr cpx; reactive oxygen; cpx; trichophyton interdigitale ... See more keywords
Ciclopirox Olamine Exerts Tumor-Suppressor Effects via Topoisomerase II Alpha in Lung Adenocarcinoma
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.791916
Abstract: Background Globally, lung cancer is one of the most malignant tumors, of which lung adenocarcinoma (LUAD) is the most common subtype, with a particularly poor prognosis. Ciclopirox olamine (CPX) is an antifungal drug and was… read more here.
Keywords: luad; topoisomerase alpha; suppressor effects; ciclopirox olamine ... See more keywords
Ciclopirox Olamine Induces Proliferation Inhibition and Protective Autophagy in Hepatocellular Carcinoma
Sign Up to like & getrecommendations! Published in 2023 at "Pharmaceuticals"
DOI: 10.3390/ph16010113
Abstract: Hepatocellular carcinoma is one of the most common fatal malignancies worldwide. Thus far, the hepatocellular carcinoma prognosis has been bleak due to deficiencies in the identification and diagnosis of early hepatocellular carcinoma. Ciclopirox olamine (CPX)… read more here.
Keywords: hepatocellular carcinoma; cpx; anti cancer; ciclopirox olamine ... See more keywords
Utilizing ethacrynic acid and ciclopirox olamine in liver cancer.
Sign Up to like & getrecommendations! Published in 2018 at "Oncology letters"
DOI: 10.3892/ol.2018.9472
Abstract: Once aberrantly activated, the Wnt/β-catenin pathway may result in uncontrolled proliferation and eventually cancer. Efforts to counter and inhibit this pathway are mainly directed against β-catenin, as it serves a role on the cytoplasm and… read more here.
Keywords: ciclopirox olamine; acid ciclopirox; ethacrynic acid; cancer ... See more keywords