Astragaloside IV attenuates chronic intermittent hypoxia-induced myocardial injury by modulating Ca2+ homeostasis.
Sign Up to like & getrecommendations! Published in 2020 at "Cell biochemistry and function"
DOI: 10.1002/cbf.3538
Abstract: Obstructive sleep apnea syndrome (OSAS) is an important consequence of chronic intermittent hypoxia (CIH). Astragaloside IV (AS-IV) exerts multiple protective effects in diverse diseases. However, whether AS-IV can attenuate CIH-induced myocardial injury is unclear. In… read more here.
Keywords: induced myocardial; myocardial injury; cih; intermittent hypoxia ... See more keywords
Toll-like receptor-4 deficiency alleviates chronic intermittent hypoxia-induced renal injury, inflammation, and fibrosis
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DOI: 10.1007/s11325-018-1704-9
Abstract: BackgroundObstructive sleep apnea (OSA)-associated chronic kidney disease is mainly caused by chronic intermittent hypoxia (CIH) triggered renal damage. This study aims to investigate the role of toll-like receptor-4 (TLR4) in underlying mechanism involved chronic intermittent… read more here.
Keywords: cih; deficiency; tlr4; injury ... See more keywords
Utilization of complementary and integrative healthcare by people with spinal cord injury in the Spinal Cord Injury Model Systems: A descriptive study.
Sign Up to like & getrecommendations! Published in 2021 at "Archives of physical medicine and rehabilitation"
DOI: 10.1016/j.apmr.2021.04.023
Abstract: OBJECTIVE To characterize the use of complementary and integrative healthcare (CIH) by people with spinal cord injury (SCI). DESIGN Cross-sectional self-report study. SETTING Participants were recruited from five Spinal Cord Injury Model System (SCIMS) centers… read more here.
Keywords: cih; complementary integrative; injury; integrative healthcare ... See more keywords
Chronic Intermittent Hypoxia Enhances Pathological Tau Seeding, Propagation, and Accumulation and Exacerbates Alzheimer-like Memory and Synaptic Plasticity Deficits and Molecular Signatures
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DOI: 10.1016/j.biopsych.2021.02.973
Abstract: BACKGROUND Obstructive sleep apnea, characterized by sleep fragmentation and chronic intermittent hypoxia (CIH), is a risk factor for Alzheimer's disease (AD) progression. Recent epidemiological studies point to CIH as the best predictor of developing cognitive… read more here.
Keywords: tau; tau seeding; mice; synaptic plasticity ... See more keywords
Chronic intermittent hypoxia disrupts cardiorespiratory homeostasis and gut microbiota composition in adult male guinea-pigs
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DOI: 10.1016/j.ebiom.2018.11.010
Abstract: Background Carotid body (peripheral oxygen sensor) sensitisation is pivotal in the development of chronic intermittent hypoxia (CIH)-induced hypertension. We sought to determine if exposure to CIH, modelling human sleep apnoea, adversely affects cardiorespiratory control in… read more here.
Keywords: microbiota; carotid; gut microbiota; cih ... See more keywords
Alpha adrenergic receptor signaling in the hypothalamic paraventricular nucleus is diminished by the chronic intermittent hypoxia model of sleep apnea
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DOI: 10.1016/j.expneurol.2020.113517
Abstract: Chronic intermittent hypoxia (CIH) is a model for obstructive sleep apnea. The paraventricular nucleus (PVN) of the hypothalamus has been suggested to contribute to CIH-induced exaggerated cardiorespiratory reflexes, sympathoexcitation and hypertension. This may occur, in… read more here.
Keywords: cih; paraventricular nucleus; sleep apnea; intermittent hypoxia ... See more keywords
Huperzine A, reduces brain iron overload and alleviates cognitive deficit in mice exposed to chronic intermittent hypoxia.
Sign Up to like & getrecommendations! Published in 2020 at "Life sciences"
DOI: 10.1016/j.lfs.2020.117573
Abstract: Chronic intermittent hypoxia (CIH) is a consequence of obstructive sleep apnea (OSA), which increases reactive oxygen species (ROS) generation, resulting in oxidative damage and neurocognitive impairment. This study was designed to determine whether abnormal iron… read more here.
Keywords: overload; hua; mice; iron ... See more keywords
Losartan protects against intermittent hypoxia-induced peritubular capillary loss by modulating the renal renin-angiotensin system and angiogenesis factors.
Sign Up to like & getrecommendations! Published in 2019 at "Acta biochimica et biophysica Sinica"
DOI: 10.1093/abbs/gmz136
Abstract: Obstructive sleep apnea is characterized by chronic intermittent hypoxia (CIH), which is a risk factor for renal peritubular capillary (PTC) loss, and angiotensin II receptor blockers can alleviate PTC loss. However, the mechanism by which… read more here.
Keywords: ptc loss; angiogenesis; cih induced; angiotensin ... See more keywords
Brain-derived erythropoietin protects from intermittent hypoxia-induced cardiorespiratory dysfunction and oxidative stress in mice
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DOI: 10.1093/sleep/zsy072
Abstract: Study Objectives Based on the fact that erythropoietin (Epo) administration in rodents protects against spatial learning and cognitive deficits induced by chronic intermittent hypoxia (CIH)-mediated oxidative damage, here we tested the hypothesis that Epo in… read more here.
Keywords: cih; mice; brain; intermittent hypoxia ... See more keywords
Inhibition of ERK1/2 regulates cognitive function by decreasing expression levels of PSD‐95 in the hippocampus of CIH rats
Sign Up to like & getrecommendations! Published in 2022 at "European Journal of Neuroscience"
DOI: 10.1111/ejn.15635
Abstract: Obstructive sleep apnoea syndrome (OSAS) is a potentially severe sleep disorder characterized by intermittent hypoxia, and there is growing evidence that OSAS can lead to cognitive decline. Extracellular signal‐regulated protein kinase 1/2 (ERK1/2) plays a… read more here.
Keywords: cih; cognitive function; hippocampus cih; expression ... See more keywords
Role of the p38MAPK signaling pathway in hippocampal neuron autophagy in rats with chronic intermittent hypoxia.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of neurophysiology"
DOI: 10.1152/jn.00240.2021
Abstract: This study explored the role of the p38 mitogen-activated protein kinase (MAPK) signaling pathway in hippocampal neuron autophagy in rats with chronic intermittent hypoxia (CIH). Sixty-four male Sprague-Dawley rats were randomly divided to normoxic control… read more here.
Keywords: hypoxia; group rats; group; cih veh ... See more keywords