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   Articles with "cih" as a keyword



Astragaloside IV attenuates chronic intermittent hypoxia-induced myocardial injury by modulating Ca2+ homeostasis.

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recommendations! Published in 2020 at "Cell biochemistry and function"

DOI: 10.1002/cbf.3538

Abstract: Obstructive sleep apnea syndrome (OSAS) is an important consequence of chronic intermittent hypoxia (CIH). Astragaloside IV (AS-IV) exerts multiple protective effects in diverse diseases. However, whether AS-IV can attenuate CIH-induced myocardial injury is unclear. In… read more here.

Keywords: induced myocardial; myocardial injury; cih; intermittent hypoxia ... See more keywords

Toll-like receptor-4 deficiency alleviates chronic intermittent hypoxia-induced renal injury, inflammation, and fibrosis

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recommendations! Published in 2018 at "Sleep and Breathing"

DOI: 10.1007/s11325-018-1704-9

Abstract: BackgroundObstructive sleep apnea (OSA)-associated chronic kidney disease is mainly caused by chronic intermittent hypoxia (CIH) triggered renal damage. This study aims to investigate the role of toll-like receptor-4 (TLR4) in underlying mechanism involved chronic intermittent… read more here.

Keywords: cih; deficiency; tlr4; injury ... See more keywords
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Utilization of complementary and integrative healthcare by people with spinal cord injury in the Spinal Cord Injury Model Systems: A descriptive study.

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recommendations! Published in 2021 at "Archives of physical medicine and rehabilitation"

DOI: 10.1016/j.apmr.2021.04.023

Abstract: OBJECTIVE To characterize the use of complementary and integrative healthcare (CIH) by people with spinal cord injury (SCI). DESIGN Cross-sectional self-report study. SETTING Participants were recruited from five Spinal Cord Injury Model System (SCIMS) centers… read more here.

Keywords: cih; complementary integrative; injury; integrative healthcare ... See more keywords
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Chronic Intermittent Hypoxia Enhances Pathological Tau Seeding, Propagation, and Accumulation and Exacerbates Alzheimer-like Memory and Synaptic Plasticity Deficits and Molecular Signatures

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recommendations! Published in 2021 at "Biological psychiatry"

DOI: 10.1016/j.biopsych.2021.02.973

Abstract: BACKGROUND Obstructive sleep apnea, characterized by sleep fragmentation and chronic intermittent hypoxia (CIH), is a risk factor for Alzheimer's disease (AD) progression. Recent epidemiological studies point to CIH as the best predictor of developing cognitive… read more here.

Keywords: tau; tau seeding; mice; synaptic plasticity ... See more keywords

Chronic intermittent hypoxia disrupts cardiorespiratory homeostasis and gut microbiota composition in adult male guinea-pigs

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recommendations! Published in 2018 at "EBioMedicine"

DOI: 10.1016/j.ebiom.2018.11.010

Abstract: Background Carotid body (peripheral oxygen sensor) sensitisation is pivotal in the development of chronic intermittent hypoxia (CIH)-induced hypertension. We sought to determine if exposure to CIH, modelling human sleep apnoea, adversely affects cardiorespiratory control in… read more here.

Keywords: microbiota; carotid; gut microbiota; cih ... See more keywords

Alpha adrenergic receptor signaling in the hypothalamic paraventricular nucleus is diminished by the chronic intermittent hypoxia model of sleep apnea

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recommendations! Published in 2021 at "Experimental Neurology"

DOI: 10.1016/j.expneurol.2020.113517

Abstract: Chronic intermittent hypoxia (CIH) is a model for obstructive sleep apnea. The paraventricular nucleus (PVN) of the hypothalamus has been suggested to contribute to CIH-induced exaggerated cardiorespiratory reflexes, sympathoexcitation and hypertension. This may occur, in… read more here.

Keywords: cih; paraventricular nucleus; sleep apnea; intermittent hypoxia ... See more keywords
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Huperzine A, reduces brain iron overload and alleviates cognitive deficit in mice exposed to chronic intermittent hypoxia.

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recommendations! Published in 2020 at "Life sciences"

DOI: 10.1016/j.lfs.2020.117573

Abstract: Chronic intermittent hypoxia (CIH) is a consequence of obstructive sleep apnea (OSA), which increases reactive oxygen species (ROS) generation, resulting in oxidative damage and neurocognitive impairment. This study was designed to determine whether abnormal iron… read more here.

Keywords: overload; hua; mice; iron ... See more keywords

Single-nucleus transcriptome profiling provides insights into the pathophysiology of OSA-related renal injury

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recommendations! Published in 2025 at "Scientific Reports"

DOI: 10.1038/s41598-025-23736-y

Abstract: Obstructive sleep apnea (OSA) has been demonstrated to be associated with renal injury. However, the cellular and molecular mechanisms by which chronic intermittent hypoxia (CIH), a hallmark of OSA, contributes to renal injury remain poorly… read more here.

Keywords: analysis; cih; cell; injury ... See more keywords

TRPC5-mediated NLRP3 inflammasome activation contributes to myocardial cell pyroptosis in chronic intermittent hypoxia rats

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recommendations! Published in 2024 at "Acta Cardiologica"

DOI: 10.1080/00015385.2024.2408137

Abstract: Abstract Background Chronic intermittent hypoxia (CIH) is the primary cause of myocardial inflammation in obstructive sleep apnea-hypopnea syndrome (OSAHS). Pyroptosis is a newly discovered form of programmed cell death accompanying inflammatory reactions. Our previous study… read more here.

Keywords: pyroptosis; cih; group; chronic intermittent ... See more keywords

Beneficial effects of doxycycline on atrial electrical remodelling in a rat model of atrial fibrillation

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recommendations! Published in 2025 at "Acta Cardiologica"

DOI: 10.1080/00015385.2025.2500888

Abstract: Abstract Background Previous studies showed that doxycycline (Dox) can attenuate chronic intermittent hypoxia (CIH)-induced atrial fibrosis in rats. On this basis, we further investigated the effects of Dox on CIH-induced atrial electrical remodelling. Methods Rats… read more here.

Keywords: expression levels; cih; electrical remodelling; atrial electrical ... See more keywords

Losartan protects against intermittent hypoxia-induced peritubular capillary loss by modulating the renal renin-angiotensin system and angiogenesis factors.

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recommendations! Published in 2019 at "Acta biochimica et biophysica Sinica"

DOI: 10.1093/abbs/gmz136

Abstract: Obstructive sleep apnea is characterized by chronic intermittent hypoxia (CIH), which is a risk factor for renal peritubular capillary (PTC) loss, and angiotensin II receptor blockers can alleviate PTC loss. However, the mechanism by which… read more here.

Keywords: ptc loss; angiogenesis; cih induced; angiotensin ... See more keywords