Megalin Blockade with Cilastatin Suppresses Drug-Induced Nephrotoxicity.
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DOI: 10.1681/asn.2016060606
Abstract: Nephrotoxicity induced by antimicrobial or anticancer drugs is a serious clinical problem. Megalin, an endocytic receptor expressed at the apical membranes of proximal tubules, mediates the nephrotoxicity of aminoglycosides and colistin, key antimicrobials for multidrug-resistant… read more here.
Keywords: vancomycin cisplatin; induced nephrotoxicity; cilastatin; megalin ... See more keywords