Distribution of prototypical primary cilia markers in subtypes of retinal ganglion cells
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Comparative Neurology"
DOI: 10.1002/cne.25326
Abstract: Loss of retinal ganglion cells (RGCs) underlies several forms of retinal disease including glaucomatous optic neuropathy, a leading cause of irreversible blindness. Several rare genetic disorders associated with cilia dysfunction have retinal degeneration as a… read more here.
Keywords: rgc cilia; cilia markers; ganglion cells; retinal ganglion ... See more keywords
Cell cycle arrest induced by trichoplein depletion is independent of cilia assembly
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.30693
Abstract: Cilia assembly and centriole duplication are closely coordinated with cell cycle progression, and inhibition of cilia disassembly impedes cell cycle progression. The centrosomal protein trichoplein (TCHP) has been shown to promote cell cycle progression in… read more here.
Keywords: tchp; cell; progression; cell cycle ... See more keywords
The Nuclear Arsenal of Cilia.
Sign Up to like & getrecommendations! Published in 2019 at "Developmental cell"
DOI: 10.1016/j.devcel.2019.03.009
Abstract: Several recent studies have revealed that nuclei and cilia share molecular components implicated in DNA damage response, splicing, gene expression, and sub-compartmentalization of the cell. We review evidence that exchange of components between the nucleus… read more here.
Keywords: cilia; arsenal cilia; nuclear arsenal;
Conserved role of ATP synthase in mammalian cilia.
Sign Up to like & getrecommendations! Published in 2021 at "Experimental cell research"
DOI: 10.1016/j.yexcr.2021.112520
Abstract: We previously found that ATP synthases localize to male-specific sensory cilia and control the ciliary response by regulating polycystin signalling in Caenorhabditis elegans. Herein, we discovered that the ciliary localization of ATP synthase is evolutionarily… read more here.
Keywords: atp synthase; conserved role; role atp; synthase ... See more keywords
Bioinspired Anisotropic Slippery Cilia for Stiffness-Controllable Bubble Transport.
Sign Up to like & getrecommendations! Published in 2022 at "ACS nano"
DOI: 10.1021/acsnano.2c02093
Abstract: Bubbles play a crucial role in multidisciplinary industrial applications, e.g., heat transfer and mass transfer. However, existing methods to manipulate bubbles still face many challenges, such as buoyancy inhibition, hydrostatic pressure, gas dissolving, easy deformability,… read more here.
Keywords: bioinspired anisotropic; anisotropic slippery; bubble transport; slippery cilia ... See more keywords
LPA signaling acts as a cell-extrinsic mechanism to initiate cilia disassembly and promote neurogenesis
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-20986-y
Abstract: Dynamic assembly and disassembly of primary cilia controls embryonic development and tissue homeostasis. Dysregulation of ciliogenesis causes human developmental diseases termed ciliopathies. Cell-intrinsic regulatory mechanisms of cilia disassembly have been well-studied. The extracellular cues controlling… read more here.
Keywords: cilia disassembly; initiate cilia; neurogenesis; disassembly promote ... See more keywords
Cilia distribution and polarity in the epithelial lining of the mouse middle ear cavity
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/srep45870
Abstract: The middle ear conducts sound to the cochlea for hearing. Otitis media (OM) is the most common illness in childhood. Moreover, chronic OM with effusion (COME) is the leading cause of conductive hearing loss. Clinically,… read more here.
Keywords: ear cavity; polarity; cilia; middle ear ... See more keywords
Metachronal patterns by magnetically-programmable artificial cilia surfaces for low Reynolds number fluid transport and mixing.
Sign Up to like & getrecommendations! Published in 2022 at "Soft matter"
DOI: 10.1039/d1sm01680f
Abstract: Motile cilia can produce net fluid flows at low Reynolds number because of their asymmetric motion and metachrony of collective beating. Mimicking this with artificial cilia can find application in microfluidic devices for fluid transport… read more here.
Keywords: low reynolds; artificial cilia; reynolds number; flow ... See more keywords
Coordination of eukaryotic cilia and flagella
Sign Up to like & getrecommendations! Published in 2018 at "Essays in Biochemistry"
DOI: 10.1042/ebc20180029
Abstract: Propulsion by slender cellular appendages called cilia and flagella is an ancient means of locomotion. Unicellular organisms evolved myriad strategies to propel themselves in fluid environments, often involving significant differences in flagella number, localisation and… read more here.
Keywords: biochemistry; cilia flagella; eukaryotic cilia; coordination eukaryotic ... See more keywords
A complex of distal appendage–associated kinases linked to human disease regulates ciliary trafficking and stability
Sign Up to like & getrecommendations! Published in 2021 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2018740118
Abstract: Significance Primary cilia (PC) are sensory organelles essential for the development and maintenance of adult tissues. Accordingly, dysfunction of PC causes human disorders called ciliopathies. Hence, a thorough understanding of the molecular regulation of PC… read more here.
Keywords: csnk2a1; trafficking stability; cilia; linked human ... See more keywords
Motility of efferent duct cilia aids passage of sperm cells through the male reproductive system
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Human Reproduction"
DOI: 10.1093/molehr/gaab009
Abstract: Abstract Motile cilia line the efferent ducts of the mammalian male reproductive tract. Several recent mouse studies have demonstrated that a reduced generation of multiple motile cilia in efferent ducts is associated with obstructive oligozoospermia… read more here.
Keywords: efferent duct; duct cilia; male reproductive; motility ... See more keywords