Taking Down the Primary Cilium: Pathways for Disassembly in Differentiating Cells
Sign Up to like & getrecommendations! Published in 2025 at "Bioessays"
DOI: 10.1002/bies.70060
Abstract: Primary cilia are customized subcellular signaling compartments leveraged to detect signals in diverse physiological contexts. Although prevalent throughout mammalian tissues, primary cilia are not universal. Many non‐ciliated cells derive from developmental lineages that include ciliated… read more here.
Keywords: cilia; primary cilium; primary cilia; cilium pathways ... See more keywords
Dpcd Induces Hydrocephalus Because of Partial Defects in the Inner Dynein Arms, With Abnormal Ciliary Motility.
Sign Up to like & getrecommendations! Published in 2025 at "Cytoskeleton"
DOI: 10.1002/cm.70012
Abstract: Primary ciliary dyskinesia (PCD) is a congenital disease caused by gene mutations linked to ciliary dysfunction. PCD causes different symptoms, including chronic sinusitis, infertility, situs inversus and hydrocephalus. Motile cilia on ventricular ependymal cells are… read more here.
Keywords: cilia; motility; dpcd; dpcd mice ... See more keywords
A Cell Type-Specific Role for Tubb6 in Ciliogenesis of Xenopus Epidermal Multiciliated Cells.
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DOI: 10.1002/cm.70056
Abstract: Cilia are microtubule-based organelles found on the surface of most eukaryotic cells. These microtubules are composed of α- and β-tubulin heterodimers, and different tubulin isotypes can confer distinct properties to microtubules. Despite their importance, the… read more here.
Keywords: cilia; xenopus epidermal; multiciliated cells; epidermal multiciliated ... See more keywords
Distribution of prototypical primary cilia markers in subtypes of retinal ganglion cells
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Comparative Neurology"
DOI: 10.1002/cne.25326
Abstract: Loss of retinal ganglion cells (RGCs) underlies several forms of retinal disease including glaucomatous optic neuropathy, a leading cause of irreversible blindness. Several rare genetic disorders associated with cilia dysfunction have retinal degeneration as a… read more here.
Keywords: rgc cilia; cilia markers; ganglion cells; retinal ganglion ... See more keywords
Cell cycle arrest induced by trichoplein depletion is independent of cilia assembly
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.30693
Abstract: Cilia assembly and centriole duplication are closely coordinated with cell cycle progression, and inhibition of cilia disassembly impedes cell cycle progression. The centrosomal protein trichoplein (TCHP) has been shown to promote cell cycle progression in… read more here.
Keywords: tchp; cell; progression; cell cycle ... See more keywords
The Nuclear Arsenal of Cilia.
Sign Up to like & getrecommendations! Published in 2019 at "Developmental cell"
DOI: 10.1016/j.devcel.2019.03.009
Abstract: Several recent studies have revealed that nuclei and cilia share molecular components implicated in DNA damage response, splicing, gene expression, and sub-compartmentalization of the cell. We review evidence that exchange of components between the nucleus… read more here.
Keywords: cilia; arsenal cilia; nuclear arsenal;
Conserved role of ATP synthase in mammalian cilia.
Sign Up to like & getrecommendations! Published in 2021 at "Experimental cell research"
DOI: 10.1016/j.yexcr.2021.112520
Abstract: We previously found that ATP synthases localize to male-specific sensory cilia and control the ciliary response by regulating polycystin signalling in Caenorhabditis elegans. Herein, we discovered that the ciliary localization of ATP synthase is evolutionarily… read more here.
Keywords: atp synthase; conserved role; role atp; synthase ... See more keywords
Bioinspired Anisotropic Slippery Cilia for Stiffness-Controllable Bubble Transport.
Sign Up to like & getrecommendations! Published in 2022 at "ACS nano"
DOI: 10.1021/acsnano.2c02093
Abstract: Bubbles play a crucial role in multidisciplinary industrial applications, e.g., heat transfer and mass transfer. However, existing methods to manipulate bubbles still face many challenges, such as buoyancy inhibition, hydrostatic pressure, gas dissolving, easy deformability,… read more here.
Keywords: bioinspired anisotropic; anisotropic slippery; bubble transport; slippery cilia ... See more keywords
Primary cilia and cancer: a tale of many faces
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DOI: 10.1038/s41388-025-03416-x
Abstract: Cilia are microtubule-based sensory organelles which project from the cell surface, enabling detection of mechanical and chemical stimuli from the extracellular environment. It has been shown that cilia are lost in some cancers, while others… read more here.
Keywords: cilia; cancer; cilia cancer; primary cilia ... See more keywords
LPA signaling acts as a cell-extrinsic mechanism to initiate cilia disassembly and promote neurogenesis
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-20986-y
Abstract: Dynamic assembly and disassembly of primary cilia controls embryonic development and tissue homeostasis. Dysregulation of ciliogenesis causes human developmental diseases termed ciliopathies. Cell-intrinsic regulatory mechanisms of cilia disassembly have been well-studied. The extracellular cues controlling… read more here.
Keywords: cilia disassembly; initiate cilia; neurogenesis; disassembly promote ... See more keywords
Cilia distribution and polarity in the epithelial lining of the mouse middle ear cavity
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/srep45870
Abstract: The middle ear conducts sound to the cochlea for hearing. Otitis media (OM) is the most common illness in childhood. Moreover, chronic OM with effusion (COME) is the leading cause of conductive hearing loss. Clinically,… read more here.
Keywords: ear cavity; polarity; cilia; middle ear ... See more keywords