Cilia-Associated Oxysterols Activate Smoothened.
Sign Up to like & getrecommendations! Published in 2018 at "Molecular cell"
DOI: 10.1016/j.molcel.2018.08.034
Abstract: Primary cilia are required for Smoothened to transduce vertebrate Hedgehog signals, but how Smoothened accumulates in cilia and is activated is incompletely understood. Here, we identify cilia-associated oxysterols that promote Smoothened accumulation in cilia and… read more here.
Keywords: cilia associated; oxysterols activate; associated oxysterols; hedgehog pathway ... See more keywords
The transcriptional signature associated with human motile cilia
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-66453-4
Abstract: Cilia are complex microtubule-based organelles essential to a range of processes associated with embryogenesis and tissue homeostasis. Mutations in components of these organelles or those involved in their assembly may result in a diverse set… read more here.
Keywords: motile cilia; signature; transcriptional signature; cilia associated ... See more keywords
Nuclear roles for cilia-associated proteins
Sign Up to like & getrecommendations! Published in 2017 at "Cilia"
DOI: 10.1186/s13630-017-0052-x
Abstract: Cilia appear to be derived, evolutionarily, from structures present in the ancestral (pre-ciliary) eukaryote, such as microtubule-based vesicle trafficking and chromosome segregation systems. Experimental observations suggest that the ciliary gate, the molecular complex that mediates… read more here.
Keywords: cilia associated; associated proteins; roles cilia; nuclear roles ... See more keywords
Primary cilia-associated protein IFT172 in ciliopathies
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2023.1074880
Abstract: Cilium is a highly conserved antenna-like structure protruding from the surface of the cell membrane, which is widely distributed on most mammalian cells. Two types of cilia have been described so far which include motile… read more here.
Keywords: cilia associated; intraflagellar transport; associated protein; primary cilia ... See more keywords