LPA signaling acts as a cell-extrinsic mechanism to initiate cilia disassembly and promote neurogenesis
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-20986-y
Abstract: Dynamic assembly and disassembly of primary cilia controls embryonic development and tissue homeostasis. Dysregulation of ciliogenesis causes human developmental diseases termed ciliopathies. Cell-intrinsic regulatory mechanisms of cilia disassembly have been well-studied. The extracellular cues controlling… read more here.
Keywords: cilia disassembly; initiate cilia; neurogenesis; disassembly promote ... See more keywords
LRRK1-mediated NDEL1 phosphorylation promotes cilia disassembly via dynein-2-driven retrograde intraflagellar transport
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cell Science"
DOI: 10.1242/jcs.259999
Abstract: ABSTRACT Primary cilia are antenna-like organelles that regulate growth and development via extracellular signals. However, the molecular mechanisms underlying cilia dynamics, particularly those regulating their disassembly, are not well understood. Here, we show that leucine-rich… read more here.
Keywords: driven retrograde; dynein driven; cilia disassembly; lrrk1 ... See more keywords