Diabetes Impairs Fracture Healing Through Disruption Of Cilia Formation In Osteoblasts.
Sign Up to like & getrecommendations! Published in 2021 at "Bone"
DOI: 10.1016/j.bone.2021.116176
Abstract: Diabetes-associated fracture risk and impaired fracture healing represents a serious health threat. It is well known that type 1 diabetes mellitus (T1DM) impairs fracture healing due to its effect on osteoblasts and their progenitor cells.… read more here.
Keywords: fracture; bone; cilia formation; fracture healing ... See more keywords
IFT52 plays an essential role in sensory cilia formation and neuronal sensory function in Drosophila.
Sign Up to like & getrecommendations! Published in 2022 at "Insect science"
DOI: 10.1111/1744-7917.13140
Abstract: Cilia are microtubule-based, hair-like organelles involved in sensory function or motility, playing critical roles in many physiological processes such as reproduction, organ development, and sensory perception. In insects, cilia are restricted to certain sensory neurons… read more here.
Keywords: sensory cilia; function; role; cilia formation ... See more keywords
Characterization of Primary Cilia Formation in Human ESC-Derived Retinal Organoids
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DOI: 10.1155/2023/6494486
Abstract: Objectives Primary cilia are conserved organelles found in polarized mammalian cells that regulate neuronal growth, migration, and differentiation. Proper cilia formation is essential during eye development. Our previous reports found that both amacrine and retinal… read more here.
Keywords: day; cilia formation; derived retinal; retinal organoids ... See more keywords
Rab8, Rab11, and Rab35 coordinate lumen and cilia formation during zebrafish left-right organizer development
Sign Up to like & getrecommendations! Published in 2023 at "PLOS Genetics"
DOI: 10.1371/journal.pgen.1010765
Abstract: An essential process during Danio rerio’s left-right organizer (Kupffer’s Vesicle, KV) development is for the majority of developing KV cells to form a motile cilium that extend into the KV lumen. Left-right beating of motile… read more here.
Keywords: development; cilia formation; rab8 rab11; formation ... See more keywords
The human phosphatase CDC14A modulates primary cilium length by regulating centrosomal actin nucleation
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DOI: 10.15252/embr.201846544
Abstract: CDC14A codes for a conserved proline‐directed phosphatase, and mutations in the gene are associated with autosomal‐recessive severe to profound deafness, due to defective kinocilia. A role of CDC14A in cilia formation has also been described… read more here.
Keywords: length; phosphatase; human phosphatase; cilia formation ... See more keywords
Primary Cilia Formation Does Not Rely on WNT/β-Catenin Signaling
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2021.623753
Abstract: Primary cilia act as crucial regulators of embryo development and tissue homeostasis. They are instrumental for modulation of several signaling pathways, including Hedgehog, WNT, and TGF-β. However, gaps exist in our understanding of how cilia… read more here.
Keywords: catenin signaling; cilia formation; catenin; wnt catenin ... See more keywords
Short-Chain Fatty Acid Butyrate Induces Cilia Formation and Potentiates the Effects of HDAC6 Inhibitors in Cholangiocarcinoma Cells
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2021.809382
Abstract: Cholangiocarcinoma (CCA) is a deadly form of liver cancer with limited therapeutic approaches. The pathogenesis of CCA involves the loss of primary cilia in cholangiocytes, an important organelle that regulates several key cellular functions including… read more here.
Keywords: cell; cilia formation; hdac6 inhibitors; butyrate ... See more keywords