Neuron‐specific cilia loss differentially alters locomotor responses to amphetamine in mice
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Neuroscience Research"
DOI: 10.1002/jnr.24755
Abstract: The neural mechanisms that underlie responses to drugs of abuse are complex, and impacted by a number of neuromodulatory peptides. Within the past 10 years it has been discovered that several of the receptors for… read more here.
Keywords: responses amphetamine; lacking cilia; cilia loss; mice lacking ... See more keywords
Up-regulated HIF-2α contributes to the Osteoarthritis development through mediating the primary cilia loss.
Sign Up to like & getrecommendations! Published in 2019 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2019.105762
Abstract: BACKGROUNDS Up-regulated HIF-2α (hypoxia induced factor 2) had been demonstrated to contribute to Osteoarthritis (OA) development via inducing the expression of matrix-degrading enzymes. However, the HIF-2α also could promote primary cilia loss through HIF-2α/AURKA (Aurora… read more here.
Keywords: hif; cilia loss; regulated hif; primary cilia ... See more keywords
Oncometabolite induced primary cilia loss in pheochromocytoma
Sign Up to like & getrecommendations! Published in 2019 at "Endocrine-Related Cancer"
DOI: 10.1530/erc-18-0134
Abstract: Primary cilia are sensory organelles involved in regulation of cellular signaling. Cilia loss is frequently observed in tumors; yet, the responsible mechanisms and consequences for tumorigenesis remain unclear. We demonstrate that cilia structure and function… read more here.
Keywords: pheochromocytoma; oncometabolite induced; induced primary; loss ... See more keywords
Pathogenic LRRK2 control of primary cilia and Hedgehog signaling in neurons and astrocytes of mouse brain
Sign Up to like & getrecommendations! Published in 2021 at "eLife"
DOI: 10.7554/elife.67900
Abstract: Activating LRRK2 mutations cause Parkinson’s disease, and pathogenic LRRK2 kinase interferes with ciliogenesis. Previously, we showed that cholinergic interneurons of the dorsal striatum lose their cilia in R1441C LRRK2 mutant mice (Dhekne et al., 2018).… read more here.
Keywords: hedgehog signaling; cilia loss; lrrk2; pathogenic lrrk2 ... See more keywords