Therapeutically actionable signaling node to rescue AURKA driven loss of primary cilia in VHL-deficient cells
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DOI: 10.1038/s41598-021-89933-7
Abstract: Loss of primary cilia in cells deficient for the tumor suppressor von Hippel Lindau (VHL) arise from elevated Aurora Kinase A (AURKA) levels. VHL in its role as an E3 ubiquitin ligase targets AURKA for… read more here.
Keywords: akt; loss primary; signaling node; primary cilia ... See more keywords