BBS4 protein has basal body/ciliary localization in sensory organs but extra-ciliary localization in oligodendrocytes during human development.
Sign Up to like & getrecommendations! Published in 2021 at "Cell and tissue research"
DOI: 10.1007/s00441-021-03440-9
Abstract: Bardet-Biedl syndrome protein 4 (BBS4) localization has been studied in human embryos/fetuses from Carnegie stage 15 to 37 gestational weeks in neurosensory organs and brain, underlying the major clinical signs of BBS. We observed a… read more here.
Keywords: localization; basal body; ciliary localization; bbs4 protein ... See more keywords
Multiple ciliary localization signals control INPP5E ciliary targeting
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.1101/2022.01.25.477585
Abstract: Primary cilia are sensory membrane protrusions whose dysfunction causes diseases named ciliopathies. INPP5E is a ciliary phosphoinositide phosphatase mutated in ciliopathies like Joubert syndrome. INPP5E regulates numerous ciliary functions, such as cilium stability, trafficking, signaling,… read more here.
Keywords: ciliary localization; inpp5e ciliary; ciliary targeting; localization signals ... See more keywords