Transcriptome sequencing reveals altered ciliogenesis under hypoxia in nasal epithelial cells from chronic rhinosinusitis with nasal polyps
Sign Up to like & getrecommendations! Published in 2022 at "Clinical and Translational Allergy"
DOI: 10.1002/clt2.12168
Abstract: Abstract Background Hypoxia is considered a key factor in the pathogenesis of chronic rhinosinusitis with nasal polyps (CRSwNP). However, the specific mechanism driving polypogenesis under hypoxic conditions is unclear. This study aimed to explore hypoxia‐induced… read more here.
Keywords: ciliogenesis; nasal polyps; nasal epithelial; hypoxia ... See more keywords
By the Tips of Your Cilia: Ciliogenesis in the Retina and the Ubiquitin-Proteasome System.
Sign Up to like & getrecommendations! Published in 2020 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-030-38266-7_13
Abstract: Primary cilia are microtubule-based sensory organelles that are involved in the organization of numerous key signals during development and in differentiated tissue homeostasis. In fact, the formation and resorption of cilia highly depends on the cell… read more here.
Keywords: ciliogenesis retina; ciliogenesis; tips cilia; retina ubiquitin ... See more keywords
Requirement of NPHP5 in the hierarchical assembly of basal feet associated with basal bodies of primary cilia
Sign Up to like & getrecommendations! Published in 2019 at "Cellular and Molecular Life Sciences"
DOI: 10.1007/s00018-019-03181-7
Abstract: During ciliogenesis, the mother centriole transforms into a basal body competent to nucleate a cilium. The mother centriole and basal body possess sub-distal appendages (SDAs) and basal feet (BF), respectively. SDAs and BF are thought… read more here.
Keywords: ciliogenesis; basal bodies; basal; basal feet ... See more keywords
Insights into photoreceptor ciliogenesis revealed by animal models
Sign Up to like & getrecommendations! Published in 2019 at "Progress in Retinal and Eye Research"
DOI: 10.1016/j.preteyeres.2018.12.004
Abstract: Photoreceptors are polarized neurons, with very specific subcellular compartmentalization and unique requirements for protein expression and trafficking. Each photoreceptor contains an outer segment, the site of photon capture that initiates vision, an inner segment that… read more here.
Keywords: ciliogenesis; connecting cilium; photoreceptor ciliogenesis; outer segment ... See more keywords
Genotoxic stress-activated DNA-PK-p53 cascade and autophagy cooperatively induce ciliogenesis to maintain the DNA damage response
Sign Up to like & getrecommendations! Published in 2021 at "Cell Death and Differentiation"
DOI: 10.1038/s41418-020-00713-8
Abstract: The DNA-PK maintains cell survival when DNA damage occurs. In addition, aberrant activation of the DNA-PK induces centrosome amplification, suggesting additional roles for this kinase. Here, we showed that the DNA-PK-p53 cascade induced primary cilia… read more here.
Keywords: dna damage; ciliogenesis; genotoxic stress; dna ... See more keywords
Ciliary defects caused by dysregulation of O-GlcNAc modification are associated with diabetic complications
Sign Up to like & getrecommendations! Published in 2018 at "Cell Research"
DOI: 10.1038/s41422-018-0114-7
Abstract: Dear Editor Diabetes is a chronic metabolic disease that has become a major epidemic worldwide. High blood glucose is thought to be the primary cause of most devastating long-term complications of diabetes. In addition to… read more here.
Keywords: ciliogenesis; information fig; supplementary information; glcnacylation ... See more keywords
M-Phase Phosphoprotein 9 regulates ciliogenesis by modulating CP110-CEP97 complex localization at the mother centriole
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-06990-9
Abstract: The primary cilium is elongated from the mother centriole and has diverse signaling roles during development and disease. The CP110-CEP97 complex functions as a negative regulator of ciliogenesis, although the mechanisms regulating its mother centriole… read more here.
Keywords: ciliogenesis; localization; mother centriole; cp110 cep97 ... See more keywords
CEP120 interacts with C2CD3 and Talpid3 and is required for centriole appendage assembly and ciliogenesis
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-42577-0
Abstract: Centrosomal protein 120 (CEP120) was originally identified as a daughter centriole-enriched protein that participates in centriole elongation. Recent studies showed that CEP120 gene mutations cause complex ciliopathy phenotypes in humans, including Joubert syndrome and Jeune… read more here.
Keywords: ciliogenesis; interacts c2cd3; c2cd3 talpid3; cep120 ... See more keywords
Ciliogenesis requires sphingolipid-dependent membrane and axoneme interaction
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2201096119
Abstract: Significance Using ribosome profiling of cilia regeneration in green algae Chlamydomonas, we uncovered that ciliary genes undergo an early transcriptional activation and late translational suppression, the pattern of which guided us to identify serine palmitoyltransferase… read more here.
Keywords: requires sphingolipid; membrane axoneme; ciliogenesis requires; ciliogenesis ... See more keywords
The HOPS complex subunit VPS39 controls ciliogenesis through autophagy
Sign Up to like & getrecommendations! Published in 2020 at "Human Molecular Genetics"
DOI: 10.1093/hmg/ddaa029
Abstract: Abstract Primary cilia are microtubule-based organelles that assemble and protrude from the surface of most mammalian cells during quiescence. The biomedical relevance of cilia is indicated by disorders ascribed to cilia dysfunction, known as ciliopathies,… read more here.
Keywords: hops complex; ciliogenesis; vps39 controls; ciliogenesis autophagy ... See more keywords
Interplay of RFX transcription factors 1, 2 and 3 in motile ciliogenesis
Sign Up to like & getrecommendations! Published in 2020 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkaa625
Abstract: Abstract Cilia assembly is under strict transcriptional control during animal development. In vertebrates, a hierarchy of transcription factors (TFs) are involved in controlling the specification, differentiation and function of multiciliated epithelia. RFX TFs play key… read more here.
Keywords: ciliogenesis; motile ciliogenesis; rfx2 rfx3; interplay rfx ... See more keywords