Targeting the HDAC6‐Cilium Axis Ameliorates the Pathological Changes Associated with Retinopathy of Prematurity
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202105365
Abstract: Retinopathy of prematurity (ROP) is one of the leading causes of childhood visual impairment and blindness. However, there are still very few effective pharmacological interventions for ROP. Histone deacetylase 6 (HDAC6)‐mediated disassembly of photoreceptor cilia… read more here.
Keywords: rop; changes associated; targeting hdac6; pathological changes ... See more keywords
Proteolysis at work: when time matters for a sensory organelle
Sign Up to like & getrecommendations! Published in 2022 at "BioEssays"
DOI: 10.1002/bies.202200137
Abstract: present in metabolism, differentiation, and development. Derangement of ciliary structures and activities underlies the pathogenesis of severe genetic disorders,alsoknownasciliopathies.Theprimaryciliumisformeddur-ing G1 phase of the and disassembled at the G2/M phase transition. Dynamics of the primary cilium… read more here.
Keywords: work time; proteolysis work; matters sensory; proteolysis ... See more keywords
A novel Cre‐inducible knock‐in ARL13B‐tRFP fusion cilium reporter
Sign Up to like & getrecommendations! Published in 2017 at "genesis"
DOI: 10.1002/dvg.23073
Abstract: Cilia play a major role in the regulation of numerous signaling pathways and are essential for embryonic development. Mutations in genes affecting ciliary function can cause a variety of diseases in humans summarized as ciliopathies.… read more here.
Keywords: reporter; cilium; arl13b trfp; trfp fusion ... See more keywords
Routes and machinery of primary cilium biogenesis
Sign Up to like & getrecommendations! Published in 2017 at "Cellular and Molecular Life Sciences"
DOI: 10.1007/s00018-017-2570-5
Abstract: Primary cilia are solitary, microtubule-based protrusions of the cell surface that play fundamental roles as photosensors, mechanosensors and biochemical sensors. Primary cilia dysfunction results in a long list of developmental and degenerative disorders that combine… read more here.
Keywords: machinery primary; epithelial cells; routes machinery; cilium ... See more keywords
Moonlighting of mitotic regulators in cilium disassembly
Sign Up to like & getrecommendations! Published in 2021 at "Cellular and Molecular Life Sciences"
DOI: 10.1007/s00018-021-03827-5
Abstract: Correct timing of cellular processes is essential during embryological development and to maintain the balance between healthy proliferation and tumour formation. Assembly and disassembly of the primary cilium, the cell’s sensory signalling organelle, are linked… read more here.
Keywords: cilium disassembly; cilium; mitotic regulators; ciliary disassembly ... See more keywords
Cyclic AMP does double duty to support parallel signaling in primary cilium and cytosol.
Sign Up to like & getrecommendations! Published in 2021 at "Cell calcium"
DOI: 10.1016/j.ceca.2021.102436
Abstract: The primary cilium maintains all of the necessary machinery to generate and interpret cAMP signals within its tiny volume, leading to the supposition that ciliary cAMP provides unique biological instructions separate from those derived from… read more here.
Keywords: cilium; cyclic amp; amp double; duty support ... See more keywords
Transient Internalization and Microtubule-Dependent Trafficking of a Ciliary Signaling Receptor from the Plasma Membrane to the Cilium
Sign Up to like & getrecommendations! Published in 2019 at "Current Biology"
DOI: 10.1016/j.cub.2019.07.022
Abstract: Cilia are ancient organelles used by unicellular and multicellular organisms not only for motility but also to receive and respond to multiple environmental cues, including light, odorants, morphogens, growth factors, and contact with cilia of… read more here.
Keywords: transient internalization; cilium; ciliary signaling; membrane ... See more keywords
Coordinating the uncoordinated: UNC119 trafficking in cilia.
Sign Up to like & getrecommendations! Published in 2017 at "European journal of cell biology"
DOI: 10.1016/j.ejcb.2017.09.001
Abstract: Constructing the distinct subcellular environment of the cilium relies in a large part upon intraflagellar transport (IFT) proteins, which traffic cargo both to and within the cilium. However, evidence from the last 10 years suggests… read more here.
Keywords: cilium; trafficking cilia; uncoordinated unc119; unc119 trafficking ... See more keywords
The primary cilium directs osteopontin-induced migration of mesenchymal stem cells by regulating CD44 signaling and Cdc42 activation.
Sign Up to like & getrecommendations! Published in 2020 at "Stem cell research"
DOI: 10.1016/j.scr.2020.101799
Abstract: The primary cilium acts as a sensory organelle with diverse receptors and ion channels to detect extracellular cues and regulate cellular functions, including cell migration. The migration of mesenchymal stem cells (MSCs) to bone remodeling… read more here.
Keywords: cilium; cd44; migration; activation ... See more keywords
The Cilium: Cellular Antenna and Central Processing Unit
Sign Up to like & getrecommendations! Published in 2017 at "Trends in Cell Biology"
DOI: 10.1016/j.tcb.2016.08.002
Abstract: Cilia mediate an astonishing diversity of processes. Recent advances provide unexpected insights into the regulatory mechanisms of cilium formation, and reveal diverse regulatory inputs that are related to the cell cycle, cytoskeleton, proteostasis, and cilia-mediated… read more here.
Keywords: cilium; antenna central; biology; cilium cellular ... See more keywords
Cell-based assay for ciliopathy patients to improve accurate diagnosis using ALPACA
Sign Up to like & getrecommendations! Published in 2021 at "European Journal of Human Genetics"
DOI: 10.1038/s41431-021-00907-9
Abstract: Skeletal ciliopathies are a group of disorders caused by dysfunction of the cilium, a small signaling organelle present on nearly every vertebrate cell. This group of disorders is marked by genetic and clinical heterogeneity, which… read more here.
Keywords: ciliopathy subgroups; cilium; diagnosis; cilium phenotype ... See more keywords