CDKL Family Kinases Have Evolved Distinct Structural Features and Ciliary Function
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DOI: 10.1016/j.celrep.2017.12.083
Abstract: Summary Various kinases, including a cyclin-dependent kinase (CDK) family member, regulate the growth and functions of primary cilia, which perform essential roles in signaling and development. Neurological disorders linked to CDK-Like (CDKL) proteins suggest that… read more here.
Keywords: evolved distinct; cilium length; family; cdkl family ... See more keywords
Genetic reduction of cilium-length by targeting intraflagellar transport 88 protein impedes kidney and liver cysts formation in mouse models of autosomal polycystic kidney disease.
Sign Up to like & getrecommendations! Published in 2020 at "Kidney international"
DOI: 10.1016/j.kint.2020.05.049
Abstract: Polycystin-1 (PC1) and -2 (PC2), products of the PKD1 and PKD2 genes, are mutated in autosomal dominant polycystic kidney disease (ADPKD). They localize to the primary cilia; however, their ciliary function is in dispute. Loss… read more here.
Keywords: kidney; intraflagellar transport; cilium length; disease ... See more keywords
C3G localizes to the mother centriole in a cenexin-dependent manner and regulates centrosome duplication and primary cilium length
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cell Science"
DOI: 10.1242/jcs.243113
Abstract: ABSTRACT C3G (also known as RAPGEF1) plays a role in cell differentiation and is essential for early embryonic development in mice. In this study, we identify C3G as a centrosomal protein that colocalizes with cenexin… read more here.
Keywords: cilium length; centrosome duplication; c3g;