An in vivo and in vitro model on the protective effect of cilnidipine on contrast‐induced nephropathy via regulation of apoptosis and CaMKⅡ/mPTP pathway
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DOI: 10.1002/jbt.23238
Abstract: Contrast‐induced nephropathy (CIN) is an acute kidney injury (AKI) observed after the administration of contrast media. Calcium channel blockers (CCBs) have been reported to exert a renal protective effect. This study aims to investigate the… read more here.
Keywords: cilnidipine; contrast; protective effect; camk ... See more keywords
Gellan gum based gastroretentive tablets for bioavailability enhancement of cilnidipine in human volunteers.
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DOI: 10.1016/j.ijbiomac.2021.01.199
Abstract: Cilnidipine, a fourth-generation both L-and N-type calcium channel blocker (CCB) is safe and effective in lowering blood-pressure without reflex tachycardia compared to other dihydropyridine CCBs. However, its low solubility coupled with extensive first-pass metabolism results… read more here.
Keywords: bioavailability; drug release; gellan gum; cilnidipine ... See more keywords
Fast Dissolving Drug Delivery System of Cilnidipine using Gelucire 50/13
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DOI: 10.5958/0974-360x.2019.00364.0
Abstract: Cilnidipine is poorly water soluble antihypertensive drug (BCS class II). This study was conducted to increase solubility of drug. An attempt was made to formulate fast dissolving tablet of Cilnidipine by solid dispersion using melting… read more here.
Keywords: drug; fast dissolving; cilnidipine; drug delivery ... See more keywords