Molecular Properties of Phosphodiesterase 4 and Its Inhibition by Roflumilast and Cilomilast
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DOI: 10.3390/molecules30030692
Abstract: Phosphodiesterase 4 (PDE4) catalyzes cyclic adenosine monophosphate (cAMP) hydrolysis, playing a crucial role in the cAMP signaling pathway. cAMP is a secondary messenger involved in numerous physiological functions, such as inflammatory responses, immune responses, neural… read more here.
Keywords: pde4; roflumilast cilomilast; inhibition; cilomilast ... See more keywords
Cilomilast Modulates Rhinovirus-Induced Airway Epithelial ICAM-1 Expression and IL-6, CXCL8 and CCL5 Production
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DOI: 10.3390/ph17111554
Abstract: Background: Cilomilast, a phosphodiesterase-4 (PDE4) selective inhibitor, has anti-inflammatory effects in vitro and in vivo and reduces COPD exacerbations. We tested the hypothesis that cilomilast inhibits virus-induced airway epithelial intercellular adhesion molecule-1 (ICAM-1) expression and… read more here.
Keywords: cilomilast; expression; cxcl8 ccl5; icam expression ... See more keywords