Transdermal Delivery of Cimetidine Across Microneedle-Treated Skin: Effect of Extent of Drug Ionization on the Permeation.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of pharmaceutical sciences"
DOI: 10.1016/j.xphs.2017.01.005
Abstract: The objective of this work was to optimize a gel formulation of cimetidine to maximize its transdermal delivery across microporated skin. Specifically, the effect of extent of ionization in formulation on permeation of cimetidine across… read more here.
Keywords: transdermal delivery; permeation; cimetidine; effect ... See more keywords
Importance of OCT2 and MATE1 for the Cimetidine-Metformin Interaction: Insights from Investigations of Polarized Transport in Single- And Double-Transfected MDCK Cells with a Focus on Perpetrator Disposition.
Sign Up to like & getrecommendations! Published in 2018 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.8b00416
Abstract: Cimetidine decreases the renal clearance of metformin by inhibition of renal tubular cation transport, and the underlying molecular mechanisms are still not fully understood. We investigated polarized metformin transport without and with the addition of… read more here.
Keywords: mdck oct2; metformin; transport; cimetidine ... See more keywords
Renal tubular transporter-mediated interactions between mirogabalin and cimetidine in rats
Sign Up to like & getrecommendations! Published in 2023 at "Xenobiotica"
DOI: 10.1080/00498254.2023.2174916
Abstract: Abstract Cimetidine at a clinical dosage decreased the renal clearance (CLr) of mirogabalin in humans by inhibition of renal secretion. Mirogabalin is a substrate of human OAT1/3, OCT2, MATE1 and/or MATE2-K. To clarify the mechanism… read more here.
Keywords: cimetidine; kidney; transporter; mirogabalin cimetidine ... See more keywords
Prevention of upper gastrointestinal bleeding in critically ill Chinese patients: a randomized, double-blind study evaluating esomeprazole and cimetidine
Sign Up to like & getrecommendations! Published in 2018 at "Current Medical Research and Opinion"
DOI: 10.1080/03007995.2018.1464132
Abstract: Abstract Objective: To assess the efficacy and safety of esomeprazole in preventing upper gastrointestinal (GI) bleeding in critically ill Chinese patients, using cimetidine as an active comparator. Methods: A pre-specified non-inferiority limit (5%) was used… read more here.
Keywords: ill chinese; cimetidine; bleeding; critically ill ... See more keywords
882: Use of Cimetidine to Reduce Dapsone-Induced Toxicity in a Non-G6PD-Deficient Transplant Recipient
Sign Up to like & getrecommendations! Published in 2020 at "Critical Care Medicine"
DOI: 10.1097/01.ccm.0000729416.23584.ed
Abstract: INTRODUCTION: Dapsone is a commonly used alternative for the prevention of Pneumocystis jirovecii pneumonia (PJP) in immunocompromised patients However, its use is limited by its significant dose-dependent hematologic adverse effects such as dapsone-induced methemoglobinemia by… read more here.
Keywords: dapsone induced; transplant; cimetidine; toxicity ... See more keywords
Acute tubulointerstitial nephritis associated with antineutrophil cytoplasmic antibody following cimetidine treatment: a case report
Sign Up to like & getrecommendations! Published in 2021 at "BMC Nephrology"
DOI: 10.1186/s12882-021-02502-y
Abstract: Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis usually induces rapidly progressive glomerulonephritis, including pauci-immune necrotizing crescentic glomerulonephritis. Acute tubulointerstitial nephritis (ATIN), which is often drug-induced, is a frequent cause of kidney injury. However, ATIN associated with ANCA… read more here.
Keywords: treatment; cimetidine; case; mpo anca ... See more keywords
Protective effect of cimetidine in carbon tetrachloride-treated rats.
Sign Up to like & getrecommendations! Published in 2019 at "Biomedical Research"
DOI: 10.35841/biomedicalresearch.30-19-063
Abstract: Cimetidine may have hepatoprotective effects. We looked for the impact of cimetidine on the hepatic changes induced by carbon tetrachloride. Male Wistar-Bratislava albino rats were randomized into four groups. Group I, control (C) received physiologic… read more here.
Keywords: treated rats; cimetidine; carbon tetrachloride; effect ... See more keywords
Repurposing cimetidine for cholangiocarcinoma: Antitumor effects in vitro and in vivo.
Sign Up to like & getrecommendations! Published in 2017 at "Oncology letters"
DOI: 10.3892/ol.2017.5563
Abstract: Cimetidine is a histamine type-2 (H2) receptor antagonist that has been demonstrated to have antitumor effects on various types of malignancy. However, its effect on cholangiocarcinoma (CCA), a chemotherapy-resistant bile duct tumor, has yet to… read more here.
Keywords: vitro vivo; cholangiocarcinoma; antitumor effects; cimetidine ... See more keywords