Comprehensive clinicopathologic, molecular, and immunologic characterization of colorectal carcinomas with loss of three intestinal markers, CDX2, SATB2, and KRT20
Sign Up to like & getrecommendations! Published in 2022 at "Virchows Archiv"
DOI: 10.1007/s00428-021-03260-w
Abstract: Caudal-type homeobox 2 (CDX2), special AT-rich sequence-binding protein 2 (SATB2), and keratin 20 (KRT20) are frequently used as intestinal epithelium-specific markers in immunohistochemical studies. However, subsets of colorectal carcinomas (CRCs) show loss of these markers.… read more here.
Keywords: expression; satb2 krt20; msi; loss ... See more keywords
Distinct clinical outcomes of two CIMP-positive colorectal cancer subtypes based on a revised CIMP classification system
Sign Up to like & getrecommendations! Published in 2017 at "British Journal of Cancer"
DOI: 10.1038/bjc.2017.52
Abstract: Background:Colorectal cancer (CRC) is a heterogeneous disease in terms of molecular carcinogenic pathways. Based on recent findings regarding the multiple serrated neoplasia pathway, we revised an eight-marker panel for a new CIMP classification system.Methods:1370 patients… read more here.
Keywords: cimp; system; colorectal cancer; cimp showed ... See more keywords
PATH-11. PROGNOSTIC SIGNIFICANCE OF EPIGENETIC SUBTYPES AND CpGs ASSOCIATED WITH PROGRESSION TO G-CIMP LOW IN THE EORTC RANDOMIZED PHASE III INTERGROUP CATNON
Sign Up to like & getrecommendations! Published in 2020 at "Neuro-oncology"
DOI: 10.1093/neuonc/noaa215.693
Abstract: Uncontrolled studies have suggested that methylation-based epigenetic subtypes can be used for prognostication of glioma. We used the prospective randomized CATNON trial to validate the clinical relevance of these epigenetic subtypes. The phase III CATNON… read more here.
Keywords: cimp; epigenetic subtypes; cimp low; idh1 2mt ... See more keywords
Abstract 5914: Colorectal cancer attributes and outcomes according to Fusobacterium nucleatum enrichment and presence
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-5914
Abstract: Purpose: Fusobacterium nucleatum (Fn) has been associated with colorectal cancer (CRC) etiology and outcomes. However, these relationships may differ by tumor attributes. We examined whether Fn enrichment and presence in CRC was associated with tumor… read more here.
Keywords: cimp; presence; enrichment presence; tumor ... See more keywords
Abstract B09: Molecular phenotyping of colorectal tumors in clinical practice: Assignment of extended prognostic subtypes by direct testing of endoscopic specimens
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Research"
DOI: 10.1158/1538-7445.crc16-b09
Abstract: Introduction: Since the pioneering work of Fearon and Vogelstein in 1990, detailed mechanisms of colorectal neoplasia have intensively been studied (1). Only recently, however, importance of molecular subtypes for prognosis has been confirmed on large… read more here.
Keywords: cimp; cin; msi; prognosis ... See more keywords
CpG Island Methylator Phenotype May Predict Poor Overall Survival of Patients with Stage IV Colorectal Cancer
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DOI: 10.1159/000493387
Abstract: Objective: We aimed to study the prognostic role of CpG island methylator phenotype (CIMP) in patients with different stages of colorectal cancer (CRC). Material and Methods: We analyzed CIMP in stage I–IV CRC specimens from… read more here.
Keywords: cimp; cpg island; island methylator; crc ... See more keywords
Unique characteristics of CpG island methylator phenotype (CIMP) in a Chinese population with colorectal cancer
Sign Up to like & getrecommendations! Published in 2019 at "BMC Gastroenterology"
DOI: 10.1186/s12876-019-1086-x
Abstract: BackgroundMolecular characteristics of CpG island methylator phenotype (CIMP) in colorectal cancer (CRC) have been well documented in Western, but not in Chinese, populations.MethodsWe investigated the incidence of CIMP, BRAF/KRAS mutation, and microsatellite instability (MSI) in… read more here.
Keywords: cimp; characteristics cpg; colorectal cancer; chinese population ... See more keywords
The CpG island methylator phenotype is concordant between primary colorectal carcinoma and matched distant metastases
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DOI: 10.1186/s13148-017-0347-1
Abstract: BackgroundThe CpG island methylator phenotype (CIMP) in stage III colon cancer (CRC) has been associated with improved survival after treatment with adjuvant irinotecan-based chemotherapy. In this analysis, we determine whether CIMP status in the primary… read more here.
Keywords: status; cimp; island methylator; cpg island ... See more keywords
Effects of Somatic Methylation in Colonic Polyps on Risk of Developing Metachronous Advanced Colorectal Lesions
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DOI: 10.3390/cancers13020246
Abstract: Simple Summary Post-polypectomy endoscopic surveillance is predominantly based on the size and number of polyps found at baseline. The utility of molecular markers for predicting the risk of metachronous advanced lesions remains poorly investigated. Patients… read more here.
Keywords: advanced colorectal; cimp; risk; risk developing ... See more keywords