The digital expression profile of BMP7, CDKN2C, HIST1H3G, and PKMYT1 genes improves high-grade cervical lesion detection in liquid-based cytology.
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DOI: 10.1002/cncy.22704
Abstract: BACKGROUND Some studies reported that differential gene expression could be used as a biomarker for high-grade cervical lesion identification. The aim was to evaluate the gene expression profile of cervical intraepithelial neoplasia (CIN) to identify… read more here.
Keywords: cin2; expression profile; expression; gene expression ... See more keywords
HPV type‐specific trends in cervical precancers in the United States, 2008 to 2016
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DOI: 10.1002/ijc.34231
Abstract: Declines in cervical intraepithelial neoplasia grades 2 to 3 and adenocarcinoma in situ (CIN2+) observed among young women suggest impact from human papillomavirus (HPV) vaccination. To further evaluate vaccine impact including cross‐protection and type replacement,… read more here.
Keywords: hpv16 cin2; cin2; type specific; hpv ... See more keywords
The use of biomarkers and HPV genotyping to improve diagnostic accuracy in women with a transformation zone type 3.
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DOI: 10.1038/s41416-021-01539-y
Abstract: BACKGROUND Twenty percent of women referred to colposcopy have a type 3 transformation zone-where colposcopic assessment for high-grade dysplasia (CIN2+) is not possible. This study examines the effectiveness of HPV biomarkers and genotyping in combination… read more here.
Keywords: dual stained; hpv genotyping; transformation zone; cin2 ... See more keywords
Risk stratification of cervical lesions using capture sequencing and machine learning method based on HPV and human integrated genomic profiles.
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DOI: 10.1093/carcin/bgz094
Abstract: From initial HPV infection and precursor stages, the development of cervical cancer takes decades. High-sensitivity HPV DNA testing is currently recommended as primary screening method for cervical cancer, while better triage methodologies are encouraged to… read more here.
Keywords: machine learning; using capture; risk stratification; cin2 ... See more keywords
Diagnostic accuracy of novel folate receptor-mediated staining solution detection (FRD) for CIN2+
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DOI: 10.1097/md.0000000000026004
Abstract: Supplemental Digital Content is available in the text Abstract Background: Early detection and diagnosis of high-grade cervical intraepithelial neoplasia grade 2 or higher (CIN2+) is critical for a good prognosis and appropriate treatment. The chief… read more here.
Keywords: tct; frd; cin2; diagnostic accuracy ... See more keywords
The clinical course of untreated CIN2 (HPV16/18+) under active monitoring: A protocol of systematic reviews and meta-analysis
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DOI: 10.1097/md.0000000000032855
Abstract: Background: Cervical cancer (CC) is one of the most prevalent and fatal cancers among women. Nearly all forms of CC are related to HPV, and 70% of invasive CCs are associated with HPV16 and HPV18.… read more here.
Keywords: cin2; untreated cin2; clinical course; course untreated ... See more keywords
Human papillomavirus genotype contribution to cervical cancer and precancer: Implications for screening and vaccination in Japan
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DOI: 10.1111/cas.14445
Abstract: To obtain baseline data for cervical cancer prevention in Japan, we analyzed human papillomavirus (HPV) data from 5045 Japanese women aged less than 40 years and diagnosed with cervical abnormalities at 21 hospitals during 2012‐2017.… read more here.
Keywords: icc; cin2; cervical cancer; human papillomavirus ... See more keywords
Test Accuracy of Human Papillomavirus in Urine for Detection of Cervical Intraepithelial Neoplasia
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DOI: 10.1128/jcm.01443-19
Abstract: The objective was to assess the diagnostic test accuracy of high-risk human papillomavirus (hrHPV) testing of self-collected urine and cervicovaginal samples for the detection of cervical intraepithelial neoplasia grade 2 or higher (CIN2+). We recruited… read more here.
Keywords: test accuracy; human papillomavirus; detection cervical; hrhpv testing ... See more keywords
77 Cervical pre-cancer vs invasive cancer: molecular differentiation with potential of improving cervical cancer screening worldwide
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DOI: 10.1136/ijgc-2019-igcs.77
Abstract: Objectives The S5 DNA-methylation classifier, based on target CpG sites of the human gene EPB41L3, and viral late gene regions of HPV-16,18,31 and 33 (Lorincz A et al., 2016) has demonstrated better performance for detection… read more here.
Keywords: pre; potential; cancer; methylation ... See more keywords
Roles of extended human papillomavirus genotyping and multiple infections in early detection of cervical precancer and cancer and HPV vaccination
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DOI: 10.1186/s12885-021-09126-3
Abstract: Background The aim of the study was to investigate the risk of human papillomavirus (HPV) genotyping particularly vaccine genotypes and multiple infections for cervical precancer and cancer, which might contribute to developing genotype-specific screening strategy… read more here.
Keywords: cancer; hpv; human papillomavirus; infection ... See more keywords
HPV-16 E2/E6 and POU5F1B as Biomarkers to Determine Cervical High-Grade Squamous Lesions and More
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DOI: 10.2147/jir.s278911
Abstract: Purpose Human papillomavirus-16 (HPV-16) is the most carcinogenic HPV genotype. This study aimed to evaluate the clinical value of POU5F1B and HPV-16-E2/E6 by cervical cytology specimens to predict the cervical intraepithelial neoplasia two grade and… read more here.
Keywords: pou5f1b; grade; cytology; pou5f1b hpv ... See more keywords