Etelcalcetide for Treating Secondary Hyperparathyroidism: An Evidence Review Group Evaluation of a NICE Single Technology Appraisal
Sign Up to like & getrecommendations! Published in 2018 at "PharmacoEconomics"
DOI: 10.1007/s40273-018-0661-2
Abstract: The manufacturer of the calcimimetic drug etelcalcetide was invited to make an evidence submission as part of the National Institute for Health and Care Excellence (NICE) Single Technology Appraisal (STA) programme. Within this submission, they… read more here.
Keywords: company; submission; evidence; review ... See more keywords
Effect of Cinacalcet in Kidney Transplant Patients With Hyperparathyroidism.
Sign Up to like & getrecommendations! Published in 2019 at "Transplantation proceedings"
DOI: 10.1016/j.transproceed.2019.01.141
Abstract: OBJECTIVE In dialysis patients, cinacalcet could be an effective alternative to parathyroidectomy for treating hyperparathyroidism. In the present study, we aimed to determine the characteristics of subjects with persistent hyperparathyroidism who require parathyroidectomy despite the… read more here.
Keywords: transplant patients; hyperparathyroidism; kidney transplant; cinacalcet ... See more keywords
Cinacalcet versus Placebo for secondary hyperparathyroidism in chronic kidney disease patients: a meta-analysis of randomized controlled trials and trial sequential analysis
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-21397-8
Abstract: To assess the efficacy and safety of cinacalcet on secondary hyperparathyroidism in patients with chronic kidney disease, Pubmed, Embase, and the Cochrane Central Register of Controlled Trials were searched until March 2016. Trial sequential analysis… read more here.
Keywords: cinacalcet; analysis; tsa adjusted; adjusted ris ... See more keywords
Formulation optimization and pharmacokinetics evaluation of oral self-microemulsifying drug delivery system for poorly water soluble drug cinacalcet and no food effect
Sign Up to like & getrecommendations! Published in 2018 at "Drug Development and Industrial Pharmacy"
DOI: 10.1080/03639045.2018.1425428
Abstract: Abstract The present research indicated that a new self-microemulsifying drug delivery systems (SMEDDS) were used to reduce the food effect of poorly water-soluble drug cinacalcet and enhance the bioavailability in beagle dogs by oral gavage.… read more here.
Keywords: methodology; food effect; drug; effect ... See more keywords
P0890EFFICACY AND SAFETY OF CINACALCET IN CHINESE MAINTENANCE HEMODIALYSIS PATIENTS WITH DIFFERENT STAGES OF SECONDARY HYPERPARATHYROIDISM: INTERIM ANALYSIS RESULTS OF ACTIVE STUDY
Sign Up to like & getrecommendations! Published in 2020 at "Nephrology Dialysis Transplantation"
DOI: 10.1093/ndt/gfaa142.p0890
Abstract: Chronic kidney disease (CKD) is a major public health issue worldwide including in China. One of the most common complication in advanced Chronic kidney disease (CKD) is secondary hyperparathyroidism (SHPT). Reports show higher risk of… read more here.
Keywords: analysis; safety; interim analysis; study ... See more keywords
Treatment of Persistent Hyperparathyroidism after Renal Transplant: Single Center Experience
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DOI: 10.1097/01.tp.0000543559.75711.c9
Abstract: Background Hyperparathyroidism is a frequent complication in chronic kidney disease and may persist after transplant in 20 to 50% of cases, manifest by hypercalcemia and hypophosphatemia. Persistent disease is associated with an increase in the… read more here.
Keywords: single center; hyperparathyroidism; treatment; renal transplant ... See more keywords
Improved Control of Secondary Hyperparathyroidism in Hemodialysis Patients Switching from Oral Cinacalcet to Intravenous Etelcalcetide, Especially in Nonadherent Patients
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DOI: 10.1159/000496562
Abstract: Background: Etelcalcetide is a novel second-generation calcimimetic that, because of its intravenous administration, could improve treatment adherence in secondary hyperparathyroidism (SHPT). The aim of this study was to evaluate the effectiveness of etelcalcetide compared with… read more here.
Keywords: hemodialysis; ipth; especially nonadherent; cinacalcet ... See more keywords
Effectiveness of cinacalcet treatment for secondary hyperparathyroidism on hospitalization: Results from the MBD-5D study
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DOI: 10.1371/journal.pone.0216399
Abstract: Objectives To elucidate the effect of cinacalcet use on all-cause and cause-specific hospitalization outcomes using a prospective cohort of maintenance hemodialysis patients. Methods We used data from a prospective cohort of Japanese hemodialysis patients with… read more here.
Keywords: cinacalcet treatment; hospitalization; cause; cinacalcet ... See more keywords
Effectiveness and safety of cinacalcet for primary hyperparathyroidism: a single center experience.
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DOI: 10.1507/endocrj.ej19-0034
Abstract: Primary hyperparathyroidism (PHPT) is a common endocrine disease. Although surgical treatment is curative in most cases, there are few alternative therapies for the hypercalcemia caused by PHPT. Cinacalcet is a positive allosteric modulator of the… read more here.
Keywords: safety cinacalcet; treatment; cinacalcet; primary hyperparathyroidism ... See more keywords
Successful use of cinacalcet monotherapy in the management of siblings with homozygous calcium-sensing receptor mutation
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Pediatric Endocrinology and Metabolism"
DOI: 10.1515/jpem-2021-0632
Abstract: Abstract Objectives Neonatal severe hyperparathyroidism (NSHPT) due to pathogenic mutations in the calcium-sensing receptor (CASR) is a serious medical condition that can lead to symptomatic hypercalcaemia and has detrimental effects on a child’s growth and… read more here.
Keywords: cinacalcet; calcium sensing; cinacalcet monotherapy; sensing receptor ... See more keywords
Successful Reversal of Furosemide-Induced Secondary Hyperparathyroidism With Cinacalcet
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DOI: 10.1542/peds.2016-3789
Abstract: Furosemide-induced SHPT is a rare complication of diuretic therapy. Cinacalcet was used successfully when traditional therapy with furosemide discontinuation, calcium, and calcitriol failed. Secondary hyperparathyroidism (SHPT) is a rare complication of furosemide therapy that can… read more here.
Keywords: successful reversal; reversal furosemide; cinacalcet; furosemide induced ... See more keywords