Cinobufagin-Loaded and Folic Acid-Modified Polydopamine Nanomedicine Combined With Photothermal Therapy for the Treatment of Lung Cancer
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DOI: 10.3389/fchem.2021.637754
Abstract: Cinobufagin is used as a traditional Chinese medicine for cancer therapy. However, it has some disadvantages, such as poor water solubility, short circulating half-life, and low bioavailability. In the present study, a targeted delivery and… read more here.
Keywords: folic acid; therapy; cinobufagin; lung cancer ... See more keywords
Antifibrotic Mechanism of Cinobufagin in Bleomycin-Induced Pulmonary Fibrosis in Mice
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DOI: 10.3389/fphar.2019.01021
Abstract: Idiopathic pulmonary fibrosis (IPF) is a progressive and usually fatal lung disease that is characterized by fibroblast proliferation and extracellular matrix remodeling, which result in irreversible distortion of the lung’s architecture and the formation of… read more here.
Keywords: bleomycin induced; fibrosis; induced pulmonary; cinobufagin ... See more keywords
Cinobufagin alleviates lipopolysaccharide-induced acute lung injury by regulating autophagy through activation of the p53/mTOR pathway
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DOI: 10.3389/fphar.2022.994625
Abstract: Acute lung injury (ALI) is a severe clinical disorder characterized by dysregulated inflammatory responses, leading to high rates of morbidity and mortality. Cinobufagin, a primary component isolated from cinobufotalin, exerts strong anticancer effects. However, there… read more here.
Keywords: lps induced; cinobufagin; induced ali; acute lung ... See more keywords
Inhibition of autophagy enhances cinobufagin‑induced apoptosis in gastric cancer.
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DOI: 10.3892/or.2018.6837
Abstract: Cinobufagin is a cardiotoxic bufanolide steroid secreted by the Asiatic toad Bufo gargarizans. Cinobufagin is one of the active ingredients in the anticancer Chinese medicine called Chan Su, which was demonstrated to be an effective treatment… read more here.
Keywords: apoptosis; gastric cancer; inhibition autophagy; cinobufagin ... See more keywords