ER stress‐related ATF6 upregulates CIP2A and contributes to poor prognosis of colon cancer
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Oncology"
DOI: 10.1002/1878-0261.12365
Abstract: Endoplasmic reticulum (ER) stress is an adaptive response to various stress conditions and plays emerging roles in cancer. Activating transcription factor 6 (ATF6), one of the three major ER stress transducers, has been shown to… read more here.
Keywords: prognosis; cip2a; stress; colon cancer ... See more keywords
Integrative assessment of CIP2A overexpression and mutational effects in human malignancies identifies possible deleterious variants.
Sign Up to like & getrecommendations! Published in 2021 at "Computers in biology and medicine"
DOI: 10.1016/j.compbiomed.2021.104986
Abstract: KIAA1524 is the gene encoding the human cancerous inhibitor of PP2A (CIP2A) protein which is regarded as a novel target for cancer therapy. It is overexpressed in 65%-90% of tissues in almost all studied human… read more here.
Keywords: cip2a overexpression; analysis; cip2a; utr variants ... See more keywords
EGFR-independent Elk1/CIP2A signalling mediates apoptotic effect of an erlotinib derivative TD52 in triple-negative breast cancer cells.
Sign Up to like & getrecommendations! Published in 2017 at "European journal of cancer"
DOI: 10.1016/j.ejca.2016.11.012
Abstract: OBJECTIVES Cancerous inhibitor of protein phosphatase 2A (CIP2A) has emerged as a therapeutic determinant mediating the anti-cancer effects of several new agents. We investigated the efficacy and mechanism of TD52, an erlotinib derivative with minimal… read more here.
Keywords: erlotinib derivative; td52; cip2a; elk1 cip2a ... See more keywords
Fusicoccin-A Targets Cancerous Inhibitor of Protein Phosphatase 2A by Stabilizing a C-Terminal Interaction with 14-3-3
Sign Up to like & getrecommendations! Published in 2022 at "ACS Chemical Biology"
DOI: 10.1021/acschembio.2c00299
Abstract: The cancerous inhibitor of protein phosphatase 2A (CIP2A) is an oncoprotein found overexpressed in many types of cancer. CIP2A has been shown to stabilize oncoproteins such as cMYC by shielding them from PP2A-mediated dephosphorylation. Here… read more here.
Keywords: cancerous inhibitor; interaction; inhibitor protein; protein phosphatase ... See more keywords
Cip2a promotes cell cycle progression in triple-negative breast cancer cells by regulating the expression and nuclear export of p27Kip1
Sign Up to like & getrecommendations! Published in 2017 at "Oncogene"
DOI: 10.1038/onc.2016.355
Abstract: Triple-negative breast cancer (TNBC) is very aggressive and currently has no specific therapeutic targets; as a consequence, TNBC exhibits poor clinical outcome. In this study, we showed that cancerous inhibitor of protein phosphatase 2A (Cip2a)… read more here.
Keywords: cell cycle; cip2a; p27kip1; tnbc ... See more keywords
Overexpression of CIP2A is associated with poor prognosis in multiple myeloma
Sign Up to like & getrecommendations! Published in 2017 at "Signal Transduction and Targeted Therapy"
DOI: 10.1038/sigtrans.2017.13
Abstract: Cancerous inhibitor of protein phosphatase 2A (CIP2A), an endogenous protein phosphatase 2A (PP2A) inhibitor, has been identified as an oncoprotein in promoting cancer initiation and progression of several types of cancer. However, the expression and… read more here.
Keywords: overexpression cip2a; prognosis; cip2a; multiple myeloma ... See more keywords
Overexpression of cancerous inhibitor ofPP2A (CIP2A) in acute myeloid leukemia
Sign Up to like & getrecommendations! Published in 2022 at "Expert Review of Hematology"
DOI: 10.1080/17474086.2022.2072825
Abstract: ABSTRACT Background Acute myeloid leukemia (AML) is a heterogeneous hematologic malignancy. Protein phosphatase 2A Protein phosphatase 2A (PP2A) is a major serine/threonine phosphatase and tumor suppressor that negatively regulates numerous signal transduction pathways. Cancerous inhibitor… read more here.
Keywords: myeloid leukemia; overexpression; cip2a overexpression; inhibitor ... See more keywords
PO-300 CIP2A-mediated regulation of senescence in basal-like breast cancer
Sign Up to like & getrecommendations! Published in 2018 at "ESMO Open"
DOI: 10.1136/esmoopen-2018-eacr25.813
Abstract: Introduction Basal-like breast cancer (BLBC) is an aggressive breast cancer molecular subtype, and it lacks efficient therapy options. Expression levels of oncoprotein CIP2A are increased in BLBC as compared to other breast cancer subtypes. Our… read more here.
Keywords: blbc; senescence; cip2a; breast cancer ... See more keywords
Prognostic significance of CIP2A expression in solid tumors: A meta-analysis
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DOI: 10.1371/journal.pone.0199675
Abstract: CIP2A, cancerous inhibitor of protein phosphatase 2A, was initially recognized as an oncoprotein. Recently several studies revealed that CIP2A could function as a prognosis biomarker, however, the result remained not comprehensive, partly due to small… read more here.
Keywords: cip2a expression; solid tumors; cip2a; meta analysis ... See more keywords
CIP2A deficiency promotes depression‐like behaviors in mice through inhibition of dendritic arborization
Sign Up to like & getrecommendations! Published in 2022 at "EMBO reports"
DOI: 10.15252/embr.202254911
Abstract: Major depressive disorder (MDD) is a severe mental illness. Decreased brain plasticity and dendritic fields have been consistently found in MDD patients and animal models; however, the underlying molecular mechanisms remain to be clarified. Here,… read more here.
Keywords: like behaviors; cip2a deficiency; dendritic arborization; depression like ... See more keywords
miR-383 Down-Regulates the Oncogene CIP2A to Influence Glioma Proliferation and Invasion
Sign Up to like & getrecommendations! Published in 2020 at "OncoTargets and therapy"
DOI: 10.2147/ott.s248116
Abstract: Background Recent evidence showed cancerous inhibitor of protein phosphatase 2A (CIP2A) plays carcinogenesis roles in several types of human cancer. However, the expression and function of CIP2A in gliomas are unknown. Methods qRT-PCR, IHC and… read more here.
Keywords: glioma; mir 383; proliferation invasion; cip2a ... See more keywords