Integrative assessment of CIP2A overexpression and mutational effects in human malignancies identifies possible deleterious variants.
Sign Up to like & getrecommendations! Published in 2021 at "Computers in biology and medicine"
DOI: 10.1016/j.compbiomed.2021.104986
Abstract: KIAA1524 is the gene encoding the human cancerous inhibitor of PP2A (CIP2A) protein which is regarded as a novel target for cancer therapy. It is overexpressed in 65%-90% of tissues in almost all studied human… read more here.
Keywords: cip2a overexpression; analysis; cip2a; utr variants ... See more keywords
Overexpression of cancerous inhibitor ofPP2A (CIP2A) in acute myeloid leukemia
Sign Up to like & getrecommendations! Published in 2022 at "Expert Review of Hematology"
DOI: 10.1080/17474086.2022.2072825
Abstract: ABSTRACT Background Acute myeloid leukemia (AML) is a heterogeneous hematologic malignancy. Protein phosphatase 2A Protein phosphatase 2A (PP2A) is a major serine/threonine phosphatase and tumor suppressor that negatively regulates numerous signal transduction pathways. Cancerous inhibitor… read more here.
Keywords: myeloid leukemia; overexpression; cip2a overexpression; inhibitor ... See more keywords