Ciproxifan, a histamine H3 receptor antagonist, reversibly inhibits monoamine oxidase A and B
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/srep40541
Abstract: Ciproxifan is a well-investigated histamine H3 receptor (H3R) inverse agonist/antagonist, showing an exclusively high species-specific affinity at rodent compared to human H3R. It is well studied as reference compound for H3R in rodent models for… read more here.
Keywords: histamine receptor; ciproxifan; monoamine oxidase;
Ciproxifan attenuates the memory impairment induced by lipopolysaccharide through modulation of cholinergic transmission in the mouse brain.
Sign Up to like & getrecommendations! Published in 2022 at "European review for medical and pharmacological sciences"
DOI: 10.26355/eurrev_202203_28335
Abstract: OBJECTIVE We investigated the protective effect of ciproxifan on lipopolysaccharide (LPS)-induced memory impairment by altering the cholinergic system in a mouse model. MATERIALS AND METHODS Groups of mice were given ciproxifan (1 or 3 mg/kg,… read more here.
Keywords: memory impairment; brain; mouse; cholinergic transmission ... See more keywords