Articles with "ciprrpob mutations" as a keyword



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Mutant RNA polymerase can reduce susceptibility to antibiotics via ppGpp-independent induction of a stringent-like response

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Published in 2020 at "Journal of Antimicrobial Chemotherapy"

DOI: 10.1093/jac/dkaa469

Abstract: Abstract Background Mutations in RNA polymerase (RNAP) can reduce susceptibility to ciprofloxacin in Escherichia coli, but the mechanism of transcriptional reprogramming responsible is unknown. Strains carrying ciprofloxacin-resistant (CipR) rpoB mutations have reduced growth fitness and… read more here.

Keywords: ciprrpob mutations; like response; susceptibility; stringent like ... See more keywords