SUGP2 p.(Arg639Gln) variant is involved in the pathogenesis of hemochromatosis via the CIRBP/BMPER signaling pathway
Sign Up to like & getrecommendations! Published in 2024 at "American Journal of Hematology"
DOI: 10.1002/ajh.27377
Abstract: Pathogenic variants in HFE and non‐HFE genes have been identified in hemochromatosis in different patient populations, but there are still a certain number of patients with unexplained primary iron overload. We recently identified in Chinese… read more here.
Keywords: arg639gln variant; hemochromatosis; sugp2 arg639gln; cirbp ... See more keywords
Cold-inducible RNA binding protein agonist enhances the cardioprotective effect of UW solution during extended heart preservation.
Sign Up to like & getrecommendations! Published in 2020 at "Artificial organs"
DOI: 10.1111/aor.13695
Abstract: In heart transplantation, time restriction is an unavoidable thorny problem during cardiac transport. Cold storage is an important organ preservation method in donor heart transport. Cold-inducible RNA binding protein (CIRBP) has been proven to play… read more here.
Keywords: cirbp; heart; heart preservation; preservation ... See more keywords
Resetting Proteostasis of CIRBP with ISRIB Suppresses Neural Stem Cell Apoptosis under Hypoxic Exposure
Sign Up to like & getrecommendations! Published in 2022 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2022/3627026
Abstract: Neurological disorders are often progressive and lead to disabilities with limited available therapies. Epidemiological evidence implicated that prolonged exposure to hypoxia leads to neurological damage and a plethora of complications. Neural stem cells (NSCs) are… read more here.
Keywords: apoptosis; cirbp; neural stem; apoptosis hypoxic ... See more keywords
CIRBP protects H9C2 cells against myocardial ischemia through inhibition of NF-κB pathway
Sign Up to like & getrecommendations! Published in 2017 at "Brazilian Journal of Medical and Biological Research"
DOI: 10.1590/1414-431x20175861
Abstract: Myocardial ischemia is a major cause of death and remains a disease with extremely deficient clinical therapies and a major problem worldwide. Cold inducible RNA-binding protein (CIRBP) is reported to be involved in multiple pathological… read more here.
Keywords: cirbp; h9c2 cells; myocardial ischemia; ischemia inhibition ... See more keywords
Promising results of a clinical feasibility study: CIRBP as a potential biomarker in pediatric cardiac surgery
Sign Up to like & getrecommendations! Published in 2024 at "Frontiers in Cardiovascular Medicine"
DOI: 10.3389/fcvm.2024.1247472
Abstract: Objective Cold-inducible RNA binding Protein (CIRBP) has been shown to be a potent inflammatory mediator and could serve as a novel biomarker for inflammation. Systemic inflammatory response syndrome (SIRS) and capillary leak syndrome (CLS) are… read more here.
Keywords: surgery; serum; cardiac surgery; cirbp ... See more keywords
CIRBP Stabilizes Slc7a11 mRNA to Sustain the SLC7A11/GPX4 Antioxidant Axis and Limit Ferroptosis in Doxorubicin-Induced Cardiotoxicity
Sign Up to like & getrecommendations! Published in 2025 at "Antioxidants"
DOI: 10.3390/antiox14080930
Abstract: Doxorubicin-induced cardiotoxicity (DIC) significantly constrains the clinical efficacy of anthracycline chemotherapy, primarily through the induction of ferroptosis, an iron-dependent, regulated cell death driven by oxidative stress and lipid peroxidation. However, the upstream regulators of ferroptosis… read more here.
Keywords: cardiotoxicity; slc7a11 mrna; ferroptosis; cirbp ... See more keywords
Dysregulation of SRSF3/circSAMD4/CIRBP Axis Promotes Iodinated Contrast-induced Acute Kidney Injury
Sign Up to like & getrecommendations! Published in 2025 at "International Journal of Biological Sciences"
DOI: 10.7150/ijbs.117838
Abstract: Iodinated contrast agents are a common cause of contrast-induced acute kidney injury (CI-AKI), yet the underlying mechanisms remain unclear. We found that circSAMD4 is markedly upregulated in renal tubular epithelial cells (RTECs) from iohexol-induced CI-AKI… read more here.
Keywords: contrast; injury; kidney injury; cirbp ... See more keywords