How circadian clocks keep time: the discovery of slowness
Sign Up to like & getrecommendations! Published in 2022 at "FEBS Letters"
DOI: 10.1002/1873-3468.14432
Abstract: Circadian clocks are biological timing systems that synchronize physiology and behavior with the daily light/dark cycle. Circadian timekeeping is based on cell-autonomous feedback loops that oscillate with a specific endogenous period under constant conditions. Recurrent… read more here.
Keywords: clocks keep; time; time discovery; circadian clocks ... See more keywords
CBC‐Clock Theory of Life – Integration of cellular circadian clocks and cellular sentience is essential for cognitive basis of life
Sign Up to like & getrecommendations! Published in 2021 at "BioEssays"
DOI: 10.1002/bies.202100121
Abstract: Cellular circadian clocks represent ancient anticipatory systems which co‐evolved with the first cells to safeguard their survival. Cyanobacteria represent one of the most ancient cells, having essentially invented photosynthesis together with redox‐based cellular circadian clocks… read more here.
Keywords: sentience; basis; circadian clocks; life ... See more keywords
Circadian Clocks Function in Concert with Heat Shock Organizing Protein to Modulate Mutant Huntingtin Aggregation and Toxicity
Sign Up to like & getrecommendations! Published in 2019 at "Cell reports"
DOI: 10.1016/j.celrep.2019.03.015
Abstract: SUMMARY Neurodegenerative diseases commonly involve the disruption of circadian rhythms. Studies indicate that mutant Huntingtin (mHtt), the cause of Huntington’s disease (HD), disrupts circadian rhythms often before motor symptoms are evident. Yet little is known… read more here.
Keywords: organizing protein; aggregation toxicity; heat shock; circadian clocks ... See more keywords
Demyelination Regulates the Circadian Transcription Factor BMAL1 to Signal Adult Neural Stem Cells to Initiate Oligodendrogenesis.
Sign Up to like & getrecommendations! Published in 2020 at "Cell reports"
DOI: 10.1016/j.celrep.2020.108394
Abstract: Circadian clocks are endogenous oscillators that generate cell-autonomous rhythms that govern cellular processes and are synchronized by external cues in the local macro- and micro-environments. Demyelination, a common brain pathology with variable degrees of recovery,… read more here.
Keywords: adult neural; circadian transcription; transcription factor; circadian clocks ... See more keywords
Circadian Clocks: Structural Plasticity on the Input Side
Sign Up to like & getrecommendations! Published in 2020 at "Current Biology"
DOI: 10.1016/j.cub.2020.06.018
Abstract: Key Drosophila clock neurons remodel their axonal arborization on a daily basis. The current view is that remodelling is part of the control of clock neuron output but new data support a major role in… read more here.
Keywords: input side; circadian clocks; biology; structural plasticity ... See more keywords
A matter of time: Circadian clocks in osteoarthritis and the potential of chronotherapy
Sign Up to like & getrecommendations! Published in 2021 at "Experimental Gerontology"
DOI: 10.1016/j.exger.2020.111163
Abstract: Osteoarthritis (OA) is a common and debilitating joint disease which develops and progresses with age. Despite extensive research into the disease, potent disease-modifying drugs remain elusive. Changes to the character and function of chondrocytes of… read more here.
Keywords: osteoarthritis potential; matter time; circadian clocks; clocks osteoarthritis ... See more keywords
Alive and Ticking: Trypanosoma brucei Assaults the Circadian Clocks.
Sign Up to like & getrecommendations! Published in 2018 at "Trends in parasitology"
DOI: 10.1016/j.pt.2018.03.003
Abstract: Rijo-Ferreira et al. report alterations of circadian rhythmicity at the behavioral, tissue, cellular, and molecular levels in mice after Trypanosoma brucei infection, showing that targeting cell clocks is a specific feature of these parasites. Thus,… read more here.
Keywords: ticking trypanosoma; assaults circadian; brucei assaults; trypanosoma brucei ... See more keywords
Diurnal oscillations of endogenous H2O2 sustained by p66Shc regulate circadian clocks
Sign Up to like & getrecommendations! Published in 2019 at "Nature Cell Biology"
DOI: 10.1038/s41556-019-0420-4
Abstract: Redox balance, an essential feature of healthy physiological steady states, is regulated by circadian clocks, but whether or how endogenous redox signalling conversely regulates clockworks in mammals remains unknown. Here, we report circadian rhythms in… read more here.
Keywords: redox signalling; endogenous h2o2; circadian clocks; h2o2 ... See more keywords
Synchrony of plant cellular circadian clocks with heterogeneous properties under light/dark cycles
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-00454-8
Abstract: Individual cells in a plant can work independently as circadian clocks, and their properties are the basis of various circadian phenomena. The behaviour of individual cellular clocks in Lemna gibba was orderly under 24-h light/dark… read more here.
Keywords: plant; dark cycles; cellular clocks; circadian clocks ... See more keywords
Circadian clocks: an overview on its adaptive significance
Sign Up to like & getrecommendations! Published in 2019 at "Biological Rhythm Research"
DOI: 10.1080/09291016.2019.1581480
Abstract: ABSTRACT The metabolic, physiological, and behavioral processes in most of the living organisms exhibit an approximate 24-h rhythmic, self-sustained circadian (L. circa = about, dies = day) oscillations. These oscillations, apart from passively persisting in… read more here.
Keywords: overview adaptive; adaptive significance; circadian clocks; clocks overview ... See more keywords
Coupling protocol of interlocked feedback oscillators in circadian clocks
Sign Up to like & getrecommendations! Published in 2020 at "Journal of the Royal Society Interface"
DOI: 10.1098/rsif.2020.0287
Abstract: Circadian rhythms (approx. 24 h) show the robustness of key oscillatory features such as phase, period and amplitude against external and internal variations. The robustness of Drosophila circadian clocks can be generated by interlocked transcriptional–translational… read more here.
Keywords: coupling protocol; protocol interlocked; circadian clocks; anti phase ... See more keywords