Phosphorylation of CLOCK and BMAL1-a key regulatory mechanism in the mammalian circadian clockwork.
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DOI: 10.1002/1873-3468.70194
Abstract: In the mammalian circadian clockwork, transcriptional-translational feedback loops are mediated by the core clock proteins, CLOCK and BMAL1. Although the transcriptional activation function of the CLOCK-BMAL1 complex has been well-characterized, the mechanisms underpinning its inactivation,… read more here.
Keywords: mammalian circadian; clock bmal1; circadian clockwork; clock ... See more keywords