Interpreting machine learning models to investigate circadian regulation and facilitate exploration of clock function
Sign Up to like & getrecommendations! Published in 2021 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2103070118
Abstract: Significance The circadian clock is an internal molecular 24-h timer that is critical to life on Earth. We describe a series of artificial intelligence (AI)– and machine learning (ML)–based approaches that enable more cost-effective analysis… read more here.
Keywords: machine learning; circadian regulation; function; dna sequence ... See more keywords
Circadian regulation of hippocampal function is disrupted with corticosteroid treatment
Sign Up to like & getrecommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2211996120
Abstract: Significance Circadian oscillations of glucocorticoids are a fundamental characteristic of adrenal hormone secretion in all mammals. These rhythms can be disrupted by chronic stress or synthetic glucocorticoid therapy, resulting in side effects including impaired memory,… read more here.
Keywords: treatment; glucocorticoid; hippocampal function; circadian regulation ... See more keywords
638 Sleep and circadian markers of BMI in a diverse sample of 9-year old children from the Fragile Families Child and Wellbeing Study
Sign Up to like & getrecommendations! Published in 2021 at "Sleep"
DOI: 10.1093/sleep/zsab072.636
Abstract: Hispanic and Black school-age children from low-income communities experience disproportionate rates of obesity (26% Hispanic, 22% Black) compared to their White counterparts (14%). Sleep patterns and circadian regulation of biological markers are associated with BMI… read more here.
Keywords: diverse sample; regulation; sleep circadian; study ... See more keywords
Circadian Regulation of Sleep in a Pre-Clinical Model of Dravet Syndrome: Dynamics of Sleep Stage and Siesta Re-entrainment.
Sign Up to like & getrecommendations! Published in 2019 at "Sleep"
DOI: 10.1093/sleep/zsz173
Abstract: STUDY OBJECTIVES Sleep disturbances are common co-morbidities of epileptic disorders. Dravet syndrome (DS) is an intractable epilepsy accompanied by disturbed sleep. While there is evidence that daily sleep timing is disrupted in DS, the difficulty… read more here.
Keywords: circadian regulation; model; sleep; dravet syndrome ... See more keywords
Circadian regulation of neutrophils: Control by a cell‐autonomous clock or systemic factors?
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Clinical Investigation"
DOI: 10.1111/eci.12965
Abstract: The circadian time‐measuring system enables the organism to anticipate and effectively respond to regular daily changes in the environment and is therefore a crucial factor of adaptation. A large body of epidemiological data underlines the… read more here.
Keywords: neutrophils control; circadian regulation; regulation neutrophils; control ... See more keywords
The flexible clock: predictive and reactive homeostasis, energy balance and the circadian regulation of sleep–wake timing
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Experimental Biology"
DOI: 10.1242/jeb.130757
Abstract: ABSTRACT The Darwinian fitness of mammals living in a rhythmic environment depends on endogenous daily (circadian) rhythms in behavior and physiology. Here, we discuss the mechanisms underlying the circadian regulation of physiology and behavior in… read more here.
Keywords: homeostasis; circadian regulation; energy; timing ... See more keywords
Circadian regulation of the Drosophila astrocyte transcriptome
Sign Up to like & getrecommendations! Published in 2021 at "PLoS Genetics"
DOI: 10.1371/journal.pgen.1009790
Abstract: Recent studies have demonstrated that astrocytes cooperate with neurons of the brain to mediate circadian control of many rhythmic processes including locomotor activity and sleep. Transcriptional profiling studies have described the overall rhythmic landscape of… read more here.
Keywords: circadian regulation; drosophila astrocyte; astrocyte transcriptome; brain ... See more keywords
Screening for key genes in circadian regulation in advanced atherosclerosis: A bioinformatic analysis
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Cardiovascular Medicine"
DOI: 10.3389/fcvm.2022.990757
Abstract: Background Atherosclerosis (AS) is the most important cardiovascular disease threatening human health, leading to adverse events such as myocardial infarction and stroke. The research on the pathogenesis and causes of AS is being improved step… read more here.
Keywords: circadian regulation; key genes; genes circadian; analysis ... See more keywords
Circadian Regulation Patterns With Distinct Immune Landscapes in Gliomas Aid in the Development of a Risk Model to Predict Prognosis and Therapeutic Response
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2021.797450
Abstract: Circadian disruption in tumorigenesis has been extensively studied, but how circadian rhythm (CR) affects the formation of tumor microenvironment (TME) and the crosstalk between TME and cancer cells is largely unknown, especially in gliomas. Herein,… read more here.
Keywords: tumor; crscore; regulation patterns; predict prognosis ... See more keywords
Control of circadian rhythm on cortical excitability and synaptic plasticity
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Neural Circuits"
DOI: 10.3389/fncir.2023.1099598
Abstract: Living organisms navigate through a cyclic world: activity, feeding, social interactions are all organized along the periodic succession of night and day. At the cellular level, periodic activity is controlled by the molecular machinery driving… read more here.
Keywords: circadian regulation; control circadian; synaptic plasticity; mtor ... See more keywords