Circadian regulator CLOCK recruits immune suppressive microglia into the GBM tumor microenvironment.
Sign Up to like & getrecommendations! Published in 2020 at "Cancer discovery"
DOI: 10.1158/2159-8290.cd-19-0400
Abstract: Glioblastoma (GBM) is a lethal brain tumor containing a subpopulation of glioma stem cells (GSCs). Pan-cancer analyses have revealed that stemness of cancer cells correlates positively with immunosuppressive pathways in many solid tumors, including GBM,… read more here.
Keywords: immune suppressive; clock; suppressive microglia; tumor ... See more keywords
Circadian Regulator CLOCK Drives Immunosuppression in Glioblastoma.
Sign Up to like & getrecommendations! Published in 2022 at "Cancer immunology research"
DOI: 10.1158/2326-6066.cir-21-0559
Abstract: The symbiotic interactions between cancer stem cells and the tumor microenvironment (TME) are critical for tumor progression. However, the molecular mechanism underlying this symbiosis in glioblastoma (GBM) remains enigmatic. Here, we show that circadian locomotor… read more here.
Keywords: regulator clock; circadian regulator; drives immunosuppression; clock drives ... See more keywords