Circadian rhythmicity of amyloid‐beta‐related molecules is disrupted in the choroid plexus of a female Alzheimer's disease mouse model
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Neuroscience Research"
DOI: 10.1002/jnr.25164
Abstract: The choroid plexus (CP) is part of the blood‐cerebrospinal fluid barrier (BCSFB) and was recently described as an important component of the circadian clock system. It is the principal source of cerebrospinal fluid (CSF) and… read more here.
Keywords: alzheimer disease; rhythmicity; expression; choroid plexus ... See more keywords
Experimental design and power calculation in omics circadian rhythmicity detection using the cosinor model.
Sign Up to like & getrecommendations! Published in 2023 at "Statistics in medicine"
DOI: 10.1002/sim.9803
Abstract: Circadian clocks are 24-h endogenous oscillators in physiological and behavioral processes. Though recent transcriptomic studies have been successful in revealing the circadian rhythmicity in gene expression, the power calculation for omics circadian analysis have not… read more here.
Keywords: power calculation; power; detection; circapower ... See more keywords
Circadian rhythmicity persists through the Polar night and midnight sun in Svalbard reindeer
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-32778-4
Abstract: Studies of locomotor activity in Svalbard reindeer reported the temporary absence of diel rhythms under Arctic photic conditions. However, using Lomb-Scargle periodogram analyses with high statistical power we found diel or circadian rhythmicity throughout the… read more here.
Keywords: rhythmicity; svalbard reindeer; heart rate; circadian rhythmicity ... See more keywords
The Role of Circadian Rhythmicity and CLOCK Genes in Psychiatry
Sign Up to like & getrecommendations! Published in 2023 at "Pharmacopsychiatry"
DOI: 10.1055/a-2078-4905
Abstract: Circadian rhythms are biological oscillations, that perpetuate themselves even in the absence of “zeitgebers” (external time cues), with a period of approximately 24 hours. The master pacemaker is the suprachiasmatic nucleus (SCN) of the hypothalamus. The… read more here.
Keywords: rhythmicity; role circadian; genes psychiatry; rhythmicity clock ... See more keywords
Homeostatic response to sleep deprivation and circadian rhythmicity are intact in older adults with insomnia.
Sign Up to like & getrecommendations! Published in 2022 at "Sleep"
DOI: 10.1093/sleep/zsac162
Abstract: STUDY OBJECTIVES We examined whether homeostatic sleep drive and circadian rhythmicity differ in older adults with insomnia (OAI) compared to older good sleepers (GS). METHODS OAI (n=37) and GS (n=30) participated in a 60-hour in-lab… read more here.
Keywords: homeostatic response; older adults; sleep deprivation; deprivation ... See more keywords
The potential of chronopharmacology for treatment of atherosclerosis
Sign Up to like & getrecommendations! Published in 2018 at "Current Opinion in Lipidology"
DOI: 10.1097/mol.0000000000000545
Abstract: Purpose of review Development of atherosclerosis contributes to cardiovascular diseases that still are the leading cause of mortality worldwide. Successful strategies for treating inflammatory aspects of atherosclerotic lesion development are rare. Here, we review new… read more here.
Keywords: potential chronopharmacology; treatment; chronopharmacology treatment; clock ... See more keywords
Hidden Markov models for monitoring circadian rhythmicity in telemetric activity data
Sign Up to like & getrecommendations! Published in 2018 at "Journal of the Royal Society Interface"
DOI: 10.1098/rsif.2017.0885
Abstract: Wearable computing devices allow collection of densely sampled real-time information on movement enabling researchers and medical experts to obtain objective and non-obtrusive records of actual activity of a subject in the real world over many… read more here.
Keywords: monitoring circadian; markov; activity data; activity ... See more keywords
Familial longevity is characterized by high circadian rhythmicity of serum cholesterol in healthy elderly individuals
Sign Up to like & getrecommendations! Published in 2017 at "Aging Cell"
DOI: 10.1111/acel.12547
Abstract: The biological clock, whose function deteriorates with increasing age, determines bodily circadian (i.e. 24h) rhythms, including that of cholesterol metabolism. Dampening of circadian rhythms has been associated with aging and disease. Therefore, we hypothesized that… read more here.
Keywords: longevity; serum cholesterol; cholesterol; circadian rhythmicity ... See more keywords
Circadian rhythmicity and the community of clockworkers
Sign Up to like & getrecommendations! Published in 2019 at "European Journal of Neuroscience"
DOI: 10.1111/ejn.14626
Abstract: The Nobel Prize in Physiology or Medicine in 2017 was awarded for the study of the molecular/cellular basis of circadian rhythms in flies. The work was on flies is an example of a principle, repeated… read more here.
Keywords: medicine; community clockworkers; rhythmicity community; physiology ... See more keywords
Is circadian rhythmicity a prerequisite to coma recovery? Circadian recovery concomitant to cognitive improvement in two comatose patients
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Pineal Research"
DOI: 10.1111/jpi.12555
Abstract: Circadian rhythmicity (CR) is involved in the regulation of all integrated functions, from sleep‐wake cycle regulation to metabolic function, mood and cognition. However, the interdependence of CR, cognition and consciousness has been poorly addressed. To… read more here.
Keywords: recovery; rhythmicity; coma; comatose patients ... See more keywords
Interval Timing Is Preserved Despite Circadian Desynchrony in Rats: Constant Light and Heavy Water Studies
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Biological Rhythms"
DOI: 10.1177/0748730417716231
Abstract: The mechanisms that enable mammals to time events that recur at 24-h intervals (circadian timing) and at arbitrary intervals in the seconds-to-minutes range (interval timing) are thought to be distinct at the computational and neurobiological… read more here.
Keywords: water; timing; constant light; interval timing ... See more keywords