Current evidence on the circadian-time-dependent effects of hypertension medications and their combinations in relation to findings of MAPEC and Hygia Chronotherapy Trial
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DOI: 10.1080/07420528.2020.1771356
Abstract: ABSTRACT The main purpose of this commentary is to update, based on our extensive review of the published literature of the past 45 yrs, the differential therapeutic effects of hypertension medications of various classes and… read more here.
Keywords: hypertension medications; time; time dependent; hypertension ... See more keywords
Development of model based on clock gene expression of human hair follicle cells to estimate circadian time
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DOI: 10.1080/07420528.2020.1777150
Abstract: ABSTRACT Considering the effects of circadian misalignment on human pathophysiology and behavior, it is important to be able to detect an individual’s endogenous circadian time. We developed an endogenous Clock Estimation Model (eCEM) based on… read more here.
Keywords: hair follicle; follicle cells; time; model ... See more keywords
Endogenous circadian time genes expressions in the liver of mice under constant darkness
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DOI: 10.1186/s12864-020-6639-4
Abstract: Background The circadian rhythms regulate physiological functions and metabolism. Circadian Time (CT) is a unit to quantify the rhythm of endogenous circadian clock, independent of light influence. To understand the gene expression changes throughout CT,… read more here.
Keywords: endogenous circadian; oscillation; constant darkness; circadian time ... See more keywords
The Mammalian Circadian Time-Keeping System.
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DOI: 10.3233/jhd-230571
Abstract: Our physiology and behavior follow precise daily programs that adapt us to the alternating opportunities and challenges of day and night. Under experimental isolation, these rhythms persist with a period of approximately one day (circadian),… read more here.
Keywords: time; circadian time; time keeping; mammalian circadian ... See more keywords
An Optimal Time for Treatment—Predicting Circadian Time by Machine Learning and Mathematical Modelling
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DOI: 10.3390/cancers12113103
Abstract: Simple Summary Personalized cancer treatments show decreased side-effects and improved treatment success. One aspect of individualized treatment is the timing of medicine intake, which may be optimized based on the biological diurnal rhythm of the… read more here.
Keywords: medicine; machine learning; treatment; time ... See more keywords