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   Articles with "circhipk3" as a keyword



CircHIPK3 promotes proliferation and invasion in nasopharyngeal carcinoma by abrogating miR‐4288‐induced ELF3 inhibition

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recommendations! Published in 2019 at "Journal of Cellular Physiology"

DOI: 10.1002/jcp.27041

Abstract: Circular RNAs (circRNAs) are reported to regulate the development and progression of multiple cancers. However, the functions of circRNAs in nasopharyngeal carcinoma (NPC) are unclear. In this study, we identified that circular homeodomain interacting protein… read more here.

Keywords: circhipk3; nasopharyngeal carcinoma; npc; mir 4288 ... See more keywords

CircHIPK3/miR-124 affects angiogenesis in early-onset preeclampsia via CPT1A-mediated fatty acid oxidation

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recommendations! Published in 2024 at "Journal of Molecular Medicine"

DOI: 10.1007/s00109-024-02461-5

Abstract: Multiple theories have been proposed to explain the pathogenesis of early-onset preeclampsia (EOPE), and angiogenic dysfunction is an important part of this pathogenesis. Carnitine palmitoyltransferase (CPT1A) is a key rate-limiting enzyme in the metabolic process… read more here.

Keywords: cpt1a; expression; eope; mir 124 ... See more keywords

Circular RNA HIPK3 exerts oncogenic properties through suppression of miR-124 in lung cancer.

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recommendations! Published in 2018 at "Biochemical and biophysical research communications"

DOI: 10.1016/j.bbrc.2018.10.087

Abstract: The current study tested the expression and potential functions of circular RNA HIPK3 (circHIPK3) in human lung cancer. Our results show that circHIPK3 expression is upregulated in established (A549 line) and primary human lung cancer… read more here.

Keywords: circhipk3; mir 124; lung; lung cancer ... See more keywords

CircHIPK3 regulates melanoma cell behaviors by binding with miR-215-5p to upregulate YY1.

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recommendations! Published in 2020 at "Molecular and cellular probes"

DOI: 10.1016/j.mcp.2020.101644

Abstract: OBJECT To investigate the role of circHIPK3 in melanoma. METHODS Bioinformatics analysis and experiments including RT-qPCR, Pearson's correlation analysis, luciferase reporter, Western blot, and RIP assays were applied to explore the function and mechanism of… read more here.

Keywords: melanoma cell; cell; mir 215; circhipk3 ... See more keywords

CircHIPK3 regulates the autophagy and apoptosis of hypoxia/reoxygenation-stimulated cardiomyocytes via the miR-20b-5p/ATG7 axis

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recommendations! Published in 2021 at "Cell Death Discovery"

DOI: 10.1038/s41420-021-00448-6

Abstract: Autophagy and apoptosis are involved in myocardial ischemia/reperfusion (I/R) injury. Research indicates that circular RNA HIPK3 (circHIPK3) is crucial to cell autophagy and apoptosis in various cancer types. However, the role of circHIPK3 in the… read more here.

Keywords: cardiomyocyte autophagy; autophagy apoptosis; apoptosis; circhipk3 ... See more keywords

PDGF-BB promotes oral submucosal fibrosis by driving phenotypic transformation and autophagy in oral mucosal fibroblasts through downregulation of circHIPK3

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recommendations! Published in 2025 at "Scientific Reports"

DOI: 10.1038/s41598-025-99753-8

Abstract: Circular RNA HIPK3 (circHIPK3), known to regulate cell proliferation, migration, transformation, and autophagy in various fibrotic conditions. However, its role has not been studied in oral submucous fibrosis (OSF). Therefore, we conducted this study to… read more here.

Keywords: proliferation migration; transformation autophagy; circhipk3; pdgf ... See more keywords

Circular RNA circHIPK3 is downregulated in diabetic cardiomyopathy and overexpression of circHIPK3 suppresses PTEN to protect cardiomyocytes from high glucose-induced cell apoptosis

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recommendations! Published in 2022 at "Bioengineered"

DOI: 10.1080/21655979.2022.2031395

Abstract: ABSTRACT It has been reported that circHIPK3 can be downregulated by high glucose, suggesting its potential involvement in diabetes and diabetic complications. This study aimed to explore the role of circHIPK3 in diabetic cardiomyopathy (DC).… read more here.

Keywords: high glucose; circhipk3 downregulated; circhipk3; cell apoptosis ... See more keywords

The novel circular RNA HIPK3 accelerates the proliferation and invasion of hepatocellular carcinoma cells by sponging the micro RNA-124 or micro RNA-506/pyruvate dehydrogenase kinase 2 axis

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recommendations! Published in 2022 at "Bioengineered"

DOI: 10.1080/21655979.2022.2031398

Abstract: ABSTRACT Circular RNAs (circRNAs) have been confirmed to be associated with the progression of various cancers, including hepatocellular carcinoma (HCC). However, the role and mechanism of circHIPK3 in HCC are still unclear. To investigate its… read more here.

Keywords: mir 124; micro rna; hcc; circhipk3 ... See more keywords

Circular RNA HIPK3 aggravates sepsis-induced acute kidney injury via modulating the microRNA-338/forkhead box A1 axis

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recommendations! Published in 2022 at "Bioengineered"

DOI: 10.1080/21655979.2022.2032974

Abstract: ABSTRACT Circular RNAs (circRNAs) have been extensively studied in various diseases, including sepsis-induced acute kidney injury (AKI). This research intended to elucidate the mechanism of circular RNA HIPK3 (circHIPK3) in sepsis-engendered AKI. Human tubule epithelial… read more here.

Keywords: injury; sepsis induced; mir 338; cell ... See more keywords

circHIPK3 regulates cell proliferation and migration by sponging microRNA-124 and regulating serine/threonine kinase 3 expression in esophageal squamous cell carcinoma

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recommendations! Published in 2022 at "Bioengineered"

DOI: 10.1080/21655979.2022.2060776

Abstract: ABSTRACT Circular RNAs (circRNAs) are a type of important non-coding RNAs that widely involve in the physiological and pathophysiological process. Recent research has established a link between circHIPK3 and the malignant activity of cancer cells.… read more here.

Keywords: cell carcinoma; circhipk3; squamous cell; expression ... See more keywords

CircHIPK3 prevents chondrocyte apoptosis and cartilage degradation by sponging miR‐30a‐3p and promoting PON2

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recommendations! Published in 2022 at "Cell Proliferation"

DOI: 10.1111/cpr.13285

Abstract: Osteoarthritis (OA) is a common joint disease featured by the deterioration of articular cartilage and chondrocyte death. Emerging evidence has indicated that circular RNAs (circRNAs) play an essential role in OA progress. Here, we found… read more here.

Keywords: apoptosis; chondrocyte apoptosis; circhipk3; cartilage ... See more keywords