Biotransformation of betulinic acid by Circinella muscae and Cunninghamella echinulata to discover anti-inflammatory derivatives.
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DOI: 10.1016/j.phytochem.2020.112608
Abstract: Biotransformation of betulinic acid was carried out with Circinella muscae CGMCC 3.2695 and Cunninghamella echinulata CGMCC 3.970, yielded six previously undescribed hydroxylated metabolites and four known compounds. C. muscae could catalyze the regioselecitve hydroxylation and… read more here.
Keywords: biotransformation betulinic; cunninghamella echinulata; circinella muscae; betulinic acid ... See more keywords
Microbial hydroxylation and glycosidation of oleanolic acid by Circinella muscae and their anti-inflammatory activities
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DOI: 10.1080/14786419.2018.1477150
Abstract: Abstract Biotransformation of oleanolic acid (OA) by Circinella muscae AS 3.2695 was investigated. Nine hydroxylated and glycosylated metabolites (1–9) were obtained. Their structures were elucidated as 3β,7β-dihydroxyolean-12-en-28-oic acid (1), 3β,7β,21β-trihydroxyolean-12-en-28-oic acid (2), 3β,7α,21β-trihydroxyolean-12-en- 28-oic acid… read more here.
Keywords: acid circinella; circinella muscae; acid; oleanolic acid ... See more keywords