Methods for Predicting CircRNA-miRNA-mRNA Regulatory Networks: GreenCircRNA and PlantCircNet Databases as Study Cases.
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DOI: 10.1007/978-1-0716-1645-1_11
Abstract: Circular RNAs are molecules formed by 3'-5' ligation in a splicing reaction, the so-called backsplicing. Well described in other groups, especially in humans, circRNA studies that include prediction and validation in plants are recent. It… read more here.
Keywords: predicting circrna; methods predicting; circrna mirna; regulatory networks ... See more keywords
A regulatory role of circRNA-miRNA-mRNA network in osteoblast differentiation.
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DOI: 10.1016/j.biochi.2021.11.001
Abstract: Osteoblast differentiation is an important process in skeletal development and bone remodelling. Serious bone diseases occur from any delay, defect, or imbalance in osteoblastic differentiation. Non-coding RNAs (ncRNAs) play a regulatory role in controlling the… read more here.
Keywords: regulatory role; role circrna; differentiation; circrna mirna ... See more keywords
Identification of key genes and construction of CircRNA–miRNA–mRNA regulatory networks in osteoarthritis
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DOI: 10.1016/j.ejbt.2018.11.004
Abstract: Background: Osteoarthritis (OA) is one of the most frequent degenerative joint diseases with high rate of disability, but its mode of action remains largely unclear. The current study was aimed at identifying key genes and… read more here.
Keywords: circrna mirna; regulatory networks; mrna regulatory; signaling pathway ... See more keywords
Profiling and Integrated Analysis of the ERCC6-regulated circRNA-miRNA-mRNA Network in Lens Epithelial Cells
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DOI: 10.1080/02713683.2021.1896742
Abstract: ABSTRACT Purpose: To explore the regulatory role of ERCC6 in the circRNA-miRNA-mRNA network using a cellular ERCC6 overexpression model (OE-ERCC6) in lens epithelial cells. Methods: The expression profiles of circRNAs, miRNAs and mRNAs were determined… read more here.
Keywords: mrna network; mirna mrna; circrna mirna;
Bioinformatics analysis of the circRNA-miRNA-mRNA network for atrial fibrillation
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DOI: 10.1097/md.0000000000030221
Abstract: Atrial fibrillation (AF) is a chronic and progressive disease, with advancing age, the morbidity of which will increase exponentially. Circular ribonucleic acids (RNAs; circRNAs) have gained a growing attention in the development of AF in… read more here.
Keywords: network; atrial fibrillation; circrna mirna; mirna mrna ... See more keywords
Construction of the circRNA-miRNA-mRNA Regulatory Network of an Abdominal Aortic Aneurysm to Explore Its Potential Pathogenesis
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DOI: 10.1155/2021/9916881
Abstract: Background Abdominal aortic aneurysm (AAA) is a progressive cardiovascular disease, which is a permanent and localized dilatation of the abdominal aorta with potentially fatal consequence of aortic rupture. Dysregulation of circRNAs is correlated with the… read more here.
Keywords: network; hsa; circrna mirna; abdominal aortic ... See more keywords
Possible epigenetic regulatory effect of dysregulated circular RNAs in epilepsy
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DOI: 10.1371/journal.pone.0209829
Abstract: Circular RNAs (circRNAs) involve in the epigenetic regulation and its major mechanism is the sequestration of the target micro RNAs (miRNAs). We hypothesized that circRNAs might be related with the pathophysiology of chronic epilepsy and… read more here.
Keywords: circular rnas; target; expression; circrna mirna ... See more keywords
Identification of circRNA-miRNA-mRNA regulatory network and its role in cardiac hypertrophy
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DOI: 10.1371/journal.pone.0279638
Abstract: Background Hypertrophic cardiomyopathy (HCM) is a grave hazard to human health. Circular RNA (circRNAs) and micro RNA (miRNAs), which are competitive endogenous RNA, have been shown to play a critical role inHCM pathogenicity. However, to… read more here.
Keywords: network; circrna mirna; mirna mrna; hypertrophy ... See more keywords
Integrated Analysis of circRNA-miRNA-mRNA-Mediated Network and Its Potential Function in Atrial Fibrillation
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DOI: 10.3389/fcvm.2022.883205
Abstract: Background Atrial fibrillation (AF) is one of the most prevalent arrhythmias, characterized by a high risk of heart failure and embolic stroke. Competing endogenous RNA network has been reported to play an important role in… read more here.
Keywords: circrna; network; mrna mediated; circrna mirna ... See more keywords
The roles of circRNA–miRNA–mRNA networks in the development and treatment of osteoporosis
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DOI: 10.3389/fendo.2022.945310
Abstract: Osteoporosis is a systemic metabolic disease, mainly characterized by reduced bone mineral density and destruction of bone tissue microstructure. However, the molecular mechanisms of osteoporosis need further investigation and exploration. Increasing studies have reported that… read more here.
Keywords: treatment osteoporosis; circrna mirna; mirna mrna; osteoporosis ... See more keywords
Systematic Identification of circRNA–miRNA–mRNA Regulatory Network in Esophageal Squamous Cell Carcinoma
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DOI: 10.3389/fgene.2021.580390
Abstract: Background Circular RNAs (circRNAs) are described as endogenous non-coding RNAs that have been reported to play important roles in the development and progression of cancers. This study aimed to reveal the circRNA-related regulatory mechanism in… read more here.
Keywords: network; circrna; circrna mirna; mrna regulatory ... See more keywords