Parkin deficiency perturbs striatal circuit dynamics
Sign Up to like & getrecommendations! Published in 2020 at "Neurobiology of Disease"
DOI: 10.1016/j.nbd.2020.104737
Abstract: Loss-of-function mutations in the parkin-encoding PARK2 gene are a frequent cause of young-onset, autosomal recessive Parkinson's disease (PD). Parkin knockout mice have no nigro-striatal neuronal loss but exhibit abnormalities of striatal dopamine transmission and cortico-striatal… read more here.
Keywords: circuit dynamics; deficiency perturbs; parkin deficiency; circuit ... See more keywords
Recurrent circuit dynamics underlie persistent activity in the macaque frontoparietal network
Sign Up to like & getrecommendations! Published in 2020 at "eLife"
DOI: 10.7554/elife.52460
Abstract: During delayed oculomotor response tasks, neurons in the lateral intraparietal area (LIP) and the frontal eye fields (FEF) exhibit persistent activity that reflects the active maintenance of behaviorally relevant information. Despite many computational models of… read more here.
Keywords: circuit dynamics; persistent activity; frontoparietal network; activity ... See more keywords