Circular Bivalent Aptamers Enable in Vivo Stability and Recognition.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.7b04547
Abstract: Aptamers are powerful candidates for molecular imaging and targeted therapy of cancer based on such appealing features as high binding affinity, high specificity, site-specific modification and rapid tumor penetration. However, aptamers are susceptible to plasma… read more here.
Keywords: enable vivo; bivalent aptamers; aptamers enable; circular bivalent ... See more keywords
Circular bivalent aptamers enhance the activation of the regenerative signaling pathway for repairing liver injury in vivo.
Sign Up to like & getrecommendations! Published in 2023 at "Chemical communications"
DOI: 10.1039/d2cc06176g
Abstract: We developed a circular bivalent aptamer (CBA) to precisely activate membrane receptor-mediated regenerative signaling for liver repair in vivo. The CBA showed enhanced biostability and receptor binding avidity, achieving effective pathway activation and satisfactory treatment… read more here.
Keywords: regenerative signaling; circular bivalent; liver injury; pathway ... See more keywords
A versatile strategy for convenient circular bivalent functional nucleic acids construction
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DOI: 10.1093/nsr/nwac107
Abstract: ABSTRACT Functional nucleic acids (FNAs), such as aptamers, nucleic acid enzymes and riboswitches play essential roles in various fields of life sciences. Tailoring of ingenious chemical moieties toward FNAs can enhance their biomedical properties and/or… read more here.
Keywords: circular bivalent; functional nucleic; nucleic acids; versatile strategy ... See more keywords