LINC01431 Promotes Histone H4R3 Methylation to Impede HBV Covalently Closed Circular DNA Transcription by Stabilizing PRMT1
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202103135
Abstract: Covalently closed circular DNA (cccDNA) is the transcriptional template of hepatitis B virus (HBV), which interacts with both host and viral proteins to form minichromosome in the nucleus and is resistant to antiviral agents. Identification… read more here.
Keywords: circular dna; hbv; transcription; covalently closed ... See more keywords
The adaptive potential of circular DNA accumulation in ageing cells
Sign Up to like & getrecommendations! Published in 2020 at "Current Genetics"
DOI: 10.1007/s00294-020-01069-9
Abstract: Carefully maintained and precisely inherited chromosomal DNA provides long-term genetic stability, but eukaryotic cells facing environmental challenges can benefit from the accumulation of less stable DNA species. Circular DNA molecules lacking centromeres segregate randomly or… read more here.
Keywords: potential circular; dna accumulation; circular dna; dna ... See more keywords
eccDNAdb: a database of extrachromosomal circular DNA profiles in human cancers
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DOI: 10.1038/s41388-022-02286-x
Abstract: Extrachromosomal circular DNA (eccDNA) elements are circular DNA molecules that are derived from but are independent of chromosomal DNA. EccDNA is emerging as a rising star because of its ubiquitous existence in cancers and its… read more here.
Keywords: dna; database; circular dna; eccdnadb database ... See more keywords
Full-length sequencing of circular DNA viruses and extrachromosomal circular DNA using CIDER-Seq
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DOI: 10.1038/s41596-020-0301-0
Abstract: Circular DNA is ubiquitous in nature in the form of plasmids, circular DNA viruses, and extrachromosomal circular DNA (eccDNA) in eukaryotes. Sequencing of such molecules is essential to profiling virus distributions, discovering new viruses and… read more here.
Keywords: cider seq; length; circular dna; dna ... See more keywords
Folding of single-stranded circular DNA into rigid rectangular DNA accelerates its cellular uptake.
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DOI: 10.1039/c9nr08695a
Abstract: Despite the importance of the interaction between DNA and cells for its biological activity, little is known about exactly how DNA interacts with cells. To elucidate the relationship between the structural properties of DNA and… read more here.
Keywords: single stranded; stranded circular; circular dna; dna ... See more keywords
Evolution of a highly functional circular DNA aptamer in serum
Sign Up to like & getrecommendations! Published in 2020 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkaa800
Abstract: Abstract Circular DNA aptamers are powerful candidates for therapeutic applications given their dramatically enhanced biostability. Herein we report the first effort to evolve circular DNA aptamers that bind a human protein directly in serum, a… read more here.
Keywords: circular dna; dna; serum; dna aptamers ... See more keywords
Extrachromosomal circular DNA mediated spread of herbicide resistance in interspecific hybrids of pigweed.
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DOI: 10.1093/plphys/kiad281
Abstract: Extrachromosomal circular DNAs (eccDNAs) are found in many eukaryotic organisms. EccDNA-powered copy number variation plays diverse roles, from oncogenesis in humans to herbicide resistance in crop weeds. Here, we report interspecific eccDNA flow and its… read more here.
Keywords: circular dna; eccdna replicon; resistance; dna mediated ... See more keywords
Characterization of extrachromosomal circular DNA in cattle using 676 whole genome sequencing datasets.
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DOI: 10.1111/age.13269
Abstract: Extrachromosomal circular DNA (eccDNA) is an important fraction of the genome. Recent studies proved that eccDNA plays important roles in genetic variation, aging and environmental adaptation, which have drawn wide attention. However, the characteristics of… read more here.
Keywords: circular dna; dna; genome sequencing; genome ... See more keywords
Proposed model for the prediction of intrahepatic covalently closed circular DNA level in patients with chronic hepatitis B
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DOI: 10.1111/hepr.13280
Abstract: We sought to create a prediction model for intrahepatic covalently closed circular DNA (IH‐cccDNA) level in chronic hepatitis B (CHB) patients and to validate the model's predictive accuracy. read more here.
Keywords: closed circular; circular dna; covalently closed; chronic hepatitis ... See more keywords
Regulatory function of interferon‐inducible 44‐like for hepatitis B virus covalently closed circular DNA in primary human hepatocytes
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DOI: 10.1111/hepr.13722
Abstract: Curing hepatitis B virus (HBV) infection requires elimination of covalently closed circular DNA (cccDNA). Interferon (IFN)‐γ has noncytolytic antiviral potential; however, elimination of cccDNA could not be achieved. To enhance the regulatory effect, we comprehensively… read more here.
Keywords: hepatitis virus; circular dna; covalently closed; closed circular ... See more keywords
Research progress on detection methods for hepatitis B virus covalently closed circular DNA
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Viral Hepatitis"
DOI: 10.1111/jvh.13817
Abstract: Hepatitis B virus (HBV) infection remains a serious global public health problem, and HBV covalently closed circular DNA (cccDNA) in the nucleus of infected cells cannot be eliminated by current treatments and is a major… read more here.
Keywords: circular dna; detection; hepatitis virus; covalently closed ... See more keywords