Derepression of co-silenced tumor suppressor genes by nanoparticle-loaded circular ssDNA reduces tumor malignancy
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DOI: 10.1126/scitranslmed.aao6321
Abstract: Circular ssDNA can sequester inhibitory microRNAs to restore tumor suppressor gene function, thereby inhibiting tumor progression. Protecting tumor suppressors Strategies to target inactive tumor suppressor genes in cancer lag behind advances in targeting oncogenes. In… read more here.
Keywords: tumor suppressor; circular ssdna; silenced tumor; suppressor genes ... See more keywords