Clinical Proteomics for the Analysis of Circulating Extracellular Vesicles.
Sign Up to like & getrecommendations! Published in 2021 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1178-4_2
Abstract: In recent years, technical improvements in proteomics have allowed its rapid application for biomarker discovery, new drug target identification, and the study of disease progression and drug resistance. The clinical potential of circulating extracellular vesicles… read more here.
Keywords: extracellular vesicles; clinical proteomics; circulating extracellular; study ... See more keywords
Circulating extracellular vesicles are effective biomarkers for predicting response to cancer therapy
Sign Up to like & getrecommendations! Published in 2021 at "EBioMedicine"
DOI: 10.1016/j.ebiom.2021.103365
Abstract: Cancer remains one of the most challenging diseases, as many patients show limited therapeutic response to treatment. Liquid biopsy is a minimally invasive method that has the advantage of providing real-time disease information with the… read more here.
Keywords: extracellular vesicles; therapy; response; circulating extracellular ... See more keywords
Protein and miRNA profile of circulating extracellular vesicles in patients with primary sclerosing cholangitis
Sign Up to like & getrecommendations! Published in 2022 at "Scientific Reports"
DOI: 10.1038/s41598-022-06809-0
Abstract: Primary sclerosing cholangitis (PSC) is an idiopathic and heterogenous cholestatic liver disease characterized by chronic inflammation and fibrosis of the biliary tree. Currently, no effective therapies are available for this condition, whose incidence is rising.… read more here.
Keywords: circulating extracellular; extracellular vesicles; sclerosing cholangitis; protein ... See more keywords
Early assessment of circulating exosomal lncRNA-GC1 for monitoring neoadjuvant chemotherapy response in gastric cancer.
Sign Up to like & getrecommendations! Published in 2023 at "International journal of surgery"
DOI: 10.1097/js9.0000000000000249
Abstract: BACKGROUND The timing of surgery for patients with gastric cancer (GC) who undergo neoadjuvant chemotherapy (neoCT) was mainly guided by serial radiologic imaging. However, an earlier assessment was indispensable to avoid delayed treatment for nonresponders… read more here.
Keywords: extracellular vesicles; derived lncrna; lncrna gc1; gc1 ... See more keywords
Metabolic Syndrome Is Associated With Altered mRNA and miRNA Content in Human Circulating Extracellular Vesicles
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2021.687586
Abstract: As mediators of intercellular communication, circulating extracellular vehicles (EVs) can modulate tissue and cellular pathways by altering transcription profiles in recipient cells, and their content may reflect the status of their parent cells. However, whether… read more here.
Keywords: syndrome associated; associated altered; circulating extracellular; altered mrna ... See more keywords
Potential involvement of circulating extracellular vesicles and particles on exercise effects in malignancies
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2023.1121390
Abstract: Physical activity and exercise have been widely related to prevention, treatment, and control for several non-communicable diseases. In this context, there are innumerous pre-clinical and clinical evidence indicating the potential role of exercise, beyond cancer… read more here.
Keywords: exercise effects; circulating evps; potential involvement; circulating extracellular ... See more keywords
Circulating extracellular vesicles are associated with the clinical outcomes of sepsis
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2023.1150564
Abstract: Introduction Sepsis is associated with endothelial cell (EC) dysfunction, increased vascular permeability and organ injury, which may lead to mortality, acute respiratory distress syndrome (ARDS) and acute renal failure (ARF). There are no reliable biomarkers… read more here.
Keywords: sepsis; extracellular vesicles; 126 levels; mortality ... See more keywords
Circulating extracellular vesicle-containing microRNAs reveal potential pathogenesis of Alzheimer’s disease
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2022.955511
Abstract: The pathogenesis of Alzheimer’s disease (AD) remains unknown till today, hindering the research and development of AD therapeutics and diagnostics. Circulating extracellular vesicles (EVs) can be utilized as a new window to spy upon AD… read more here.
Keywords: circulating extracellular; pathogenesis alzheimer; alzheimer disease; pathogenesis ... See more keywords
Proteomics and Phosphoproteomics of Circulating Extracellular Vesicles Provide New Insights into Diabetes Pathobiology
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23105779
Abstract: The purpose of this study was to define the proteomic and phosphoproteomic landscape of circulating extracellular vesicles (EVs) in people with normal glucose tolerance (NGT), prediabetes (PDM), and diabetes (T2DM). Archived serum samples from 30… read more here.
Keywords: extracellular vesicles; pdm t2dm; phosphoproteomics circulating; pathobiology ... See more keywords
Circulating Extracellular Vesicles Impair Mesenchymal Stromal Cell Differentiation Favoring Adipogenic Rather than Osteogenic Differentiation in Adolescents with Obesity
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24010447
Abstract: Excess body weight has been considered beneficial to bone health because of its anabolic effect on bone formation; however, this results in a poor quality bone structure. In this context, we evaluated the involvement of… read more here.
Keywords: extracellular vesicles; mesenchymal stromal; obesity; differentiation ... See more keywords
Circulating Extracellular Vesicles microRNAs Are Altered in Women Undergoing Preterm Birth
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24065527
Abstract: Preterm labor (PTL) and preterm premature rupture of membranes (PPROM) lead to high perinatal morbidity/mortality rates worldwide. Small extracellular vesicles (sEV) act in cell communication and contain microRNAs that may contribute to the pathogenesis of… read more here.
Keywords: extracellular vesicles; ptl pprom; expression; term ... See more keywords