Factors that influence quality and yield of circulating-free DNA: A systematic review of the methodology literature
Sign Up to like & getrecommendations! Published in 2018 at "Heliyon"
DOI: 10.1016/j.heliyon.2018.e00699
Abstract: Background Circulating-free DNA (cfDNA) is under investigation as a liquid biopsy of cancer for early detection, monitoring disease progression and therapeutic response. This systematic review of the primary cfDNA literature aims to identify and evaluate… read more here.
Keywords: methodology; literature; systematic review; circulating free ... See more keywords
Profiling of Circulating Free DNA Using Targeted and Genome-wide Sequencing in Patients with SCLC
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Thoracic Oncology"
DOI: 10.1016/j.jtho.2019.10.007
Abstract: Introduction SCLC accounts for approximately 250,000 deaths worldwide each year. Acquisition of adequate tumor biopsy samples is challenging, and liquid biopsies present an alternative option for patient stratification and response monitoring. Methods We applied whole… read more here.
Keywords: genome wide; circulating free; patients sclc; free dna ... See more keywords
Integrating circulating-free DNA (cfDNA) analysis into clinical practice: opportunities and challenges.
Sign Up to like & getrecommendations! Published in 2022 at "British journal of cancer"
DOI: 10.1038/s41416-022-01776-9
Abstract: In the current era of precision medicine, the identification of genomic alterations has revolutionised the management of patients with solid tumours. Recent advances in the detection and characterisation of circulating tumour DNA (ctDNA) have enabled… read more here.
Keywords: dna; circulating free; integrating circulating; free dna ... See more keywords
Circulating free DNA (cfDNA) and tissue next-generation sequencing analysis in a phase II study of infigratinib (BGJ398) for cholangiocarcinoma with FGFR2 fusions.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2020.38.4_suppl.579
Abstract: 579Background: Fibroblast growth factor receptor 2 (FGFR2) alterations occur in 11% of cholangiocarcinomas, 85% of which are fusions. A multicenter, open-label, phase II study is currently evaluati... read more here.
Keywords: phase; dna cfdna; circulating free; free dna ... See more keywords
Circulating-free DNA (cfDNA) as biomarker of taxane resistance in metastatic castration-resistant prostate cancer (mCRPC).
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2020.38.6_suppl.174
Abstract: 174Background: Docetaxel (D) and cabazitaxel (C) are standard chemotherapies for mCRPC. A reliable biomarker predictive of resistance to D or C is yet to be identified. We aimed to assess the assoc... read more here.
Keywords: dna cfdna; biomarker; circulating free; free dna ... See more keywords
Diagnostic accuracy of circulating free DNA testing for the detection of KRAS mutations in non-small cell lung cancer: A systematic review and meta-analysis
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2022.1015161
Abstract: Kirsten rat sarcoma viral oncogene homolog (KRAS) gene encodes a GTPase that acts as a molecular switch for intracellular signal transduction, promoting cell growth and proliferation. Mutations in the KRAS gene represent important biomarkers for… read more here.
Keywords: detection kras; detection; kras mutations; analysis ... See more keywords
MMP-9 as a Candidate Marker of Response to BRAF Inhibitors in Melanoma Patients With BRAFV600E Mutation Detected in Circulating-Free DNA
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2018.00856
Abstract: The BRAFV600E mutation is associated with melanoma development and its detection in circulating-free DNA cannot be observed in all melanoma patients harboring this mutation in tumor specimens. Beside the circulating-free DNA BRAFV600E mutation, other markers… read more here.
Keywords: brafv600e mutation; circulating free; mutation; free dna ... See more keywords
Assessing the Concordance of Genomic Alterations between Circulating-Free DNA and Tumour Tissue in Cancer Patients
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DOI: 10.3390/cancers11121938
Abstract: Somatic alterations to the genomes of solid tumours, which in some cases represent actionable drivers, provide diagnostic and prognostic insight into these complex diseases. Spatial and longitudinal tracking of somatic genomic alterations (SGAs) in patient… read more here.
Keywords: tumour tissue; circulating free; cfdna; genomic alterations ... See more keywords